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題 名 | Characterization of Novel 10-Substituted 1,8-Dihydroxy-9(10H)-Anthracenone Derivatives by Mass Spectrometry=新型10-取代基-1,8-二羥基-9(10氫)-蒽酮衍生物在質譜之化學特性 |
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作 者 | 黃旭山; 林本元; | 書刊名 | Proceedings of the National Science Council : Part B, Life Science |
卷 期 | 24:1 2000.01[民89.01] |
頁 次 | 頁20-25 |
分類號 | 418.43 |
關鍵詞 | 10-取代基-1,8-二羥基-9(10氫)-蒽酮衍生物; 質譜; 乾癬; Psoriasis; H-migration; C-S bond cleavage; Anthralin; Chrysarobin; McLafferty rearrangement; Ipso-cleavage; |
語 文 | 英文(English) |
英文摘要 | Anthralin and its derivatives containing a variety of simple or functionalized aliphatic and aromatic substituents are of special interest in research on psoriasis. In this connection, 10-arylthio-1,8-dihydroxy-9(10H)-anthracenones were synthesized and examined by means of mass spectrometry. In general, the molecules in question fragmented upon electron impact into ions at m/z 225 (C-S bond cleavage and charge retention at the anthralin component) and into ions of unknown structure at m/z 226, requiring H-migration from the S-bound substituent R into the anthralin moiety. Since mass spectrometry methods furnished us elegant, matchless means of tracing the amounts of material in the analysis, especially in the case of physiologically active compounds, we decided to use mass spectrometry procedures for unequivocal identification and purity determination of 10-arylthio-anthralins. |
本系統中英文摘要資訊取自各篇刊載內容。