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題 名 | 臺農二號山藥與四種治療糖尿病常用中藥抗蛋白質糖基化活性之比較研究=Inhibitory Effects of the Water Yam (Dioscorea Alata L.) on Glucose-induced Protein Glycation: A Comparative Study with Four Chinese Medicines for Treating Diabetes |
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作 者 | 陳郁婷; 謝潔怡; 李宗貴; 劉新裕; 王祖興; | 書刊名 | 臺灣營養學會雜誌 |
卷 期 | 31:4 民95.12 |
頁 次 | 頁137-145 |
分類號 | 411.3 |
關鍵詞 | 臺農二號山藥; 蛋白質糖基化作用; 酚類化合物; 自由基清除力; Dioscorea alata; Protein glycation; Free-radical scavenging; Phenolics; |
語 文 | 中文(Chinese) |
中文摘要 | 糖尿病居國人十大死因的前五名,長期高血糖將造成細胞及組織蛋白質糖基化作用(glycation)及氧化壓力的增加,此現象被認為是造成糖尿病合併症重要的病理機制,因此開發兼具抗氧化及抗糖基化作用之天然物質,應可提供對糖尿病合併症預防治療之潛力。比較台農二號山藥(Dioscorea alata L.)及四種治療糖尿病常用中藥水抽出物,包括茯苓、天花粉、黃耆及澤瀉,在抗蛋白質糖基化作用及抗氧化活性上的能力。台農二號山藥、茯苓、天花粉、黃耆及澤瀉水抽出物之抗糖基化活性及抗氧化活性,分別以抑制牛血清白蛋白(BSA)糖基化作用及清除ABTS(2,2'-Azino-di-3-ethylbenZthiazoline sulphonate)自由基產生進行測量。本研究發現台農二號山藥、天花粉、黃耆及澤瀉水抽出物對熱誘導葡萄糖造成BSA糖基化都有顯著的抑制效果,其中又以天花粉水抽出物的抑制效果最好,相反的,袂苓水抽出物則明顯增強BSA糖基化。上述樣品水抽出物抑制葡萄糖造成BSA糖基化活性,與樣品中所含之總酚量呈曲線正相關(f=0.93,p<0.05),而水抽出物自由基清除力則與所含之總酚量呈現直線正相關(r=0.98,p<0.01)。本研究結果顯示氧化壓力與蛋白糖基化間密切關係外,也證實台農二號山藥、天花粉、黃耆及澤瀉都具有明顯抗蛋白質糖基化及抗氧化之雙重活性,在預防糖尿病合併症上深具開發潛力。 |
英文摘要 | Diabetes is one of the five leading causes of death in Taiwan. Diabetic hyperglycemia leads to protein glycation and oxidative stress in cells and tissues, and these have been implicated in the pathogenesis of diabetic complications. Therefore, exploring natural compounds that possess both antioxidant and antiglycation activities might have great therapeutic potential for treating diabetic complications. The object of this study was to evaluate the antiglycating and antioxidant properties of extracts from edible Shan-Yao (water yam; Dioscorea alata L.) tubers and several other traditional Chinese herbs used to treat diabetes, including Fu-Ling, Tian-Hua-Fen, Huang-Chi, and Ze-Xie by thermal glycation of bovine serum albumin (BSA) and an in vitro free radical-scavenging assay. The results showed that the water extracts of Shan-Yao, Tian-Hua-Fen, Huang-Chi, and Ze-Xie caused a significant decrease in the thermal glycation of BSA by glucose, with the extract from Tian-Hua-Fen being the most effective. The extract of Fu-Ling markedly enhanced the level of thermal glycation of BSA by glucose. The total phenolic concentration was strongly correlated with the antiglycation activity (r=0.93 p<0.05) and with the free radical-scavenging activity (r=0.98 p<0.01). The antiglycation activities of Shan-Yao, Tian-Hua-Fen, Huang-Chi, and Ze-Xie were consistent with their phenolic contents and free radical-scavenging activities. Again the lowest content of phenolics and free radical-scavenging activity were found in the extract of Fu-Ling. Our study results suggest that water extracts from Shan-Yao, Tian-Hua-Fen, Huang-Chi, and Ze-Xie, especially Tian-Hua-Fen, may offer therapeutic potential in protection against diabetic complications due to their combined antiglycation and antioxidant properties. |
本系統中英文摘要資訊取自各篇刊載內容。