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相關文獻
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頁籤選單縮合
題名 | Transfusion-transmitted Virus Infection in Renal Transplant Recipients in Eastern Taiwan=東臺灣腎臟移植病人TTV病毒感染的盛行率 |
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作者姓名(中文) | 李明哲; 王豊裕; 林憲宏; 林等義; 胡志棠; 王智賢; 方德昭; 徐邦治; | 書刊名 | 慈濟醫學 |
卷期 | 18:6 民95.12 |
頁次 | 頁427-431+467 |
分類號 | 415.5332 |
關鍵詞 | 輸血傳遞的肝炎病毒; 腎臟移植; 盛行率; Transfusion-transmitted virus; Kidney transplantation; Prevalence; |
語文 | 英文(English) |
中文摘要 | 目的:許多研究指出血液透析病人為輸血傳遞的(TT)肝炎病毒感染的高危險族群,但只有少部分研究於腎臟移植病人。而在臺灣,目前無任何研究關於腎臟移植病人和輸血傳遞的肝炎之間的關係。本研究目的即探討東臺灣腎臟移植病人輸血傳遞的肝炎病毒感染及跟輸血、B型肝炎、C型肝炎、肝功能之間的關係。病人與方法:研究對象為東臺灣23位腎臟移植病人及43位健康檢查者,抽血萃取病毒DNA再以聚合連鎖反應(polymerase chain reaction)進行輸血傳遞的肝炎病毒的檢查。結果:研究發現腎臟移植病人相對於健康檢查者有較高的輸血率(P<0.0001),C型肝炎病毒感染率(P=0.048),血中AST值(P=0.013)及血中ALT值(P=0.019)。輸血傳遞的肝炎病毒感染率在腎臟移植病人跟健康檢查者是相似的(相對上為34.8% vs 37.2%)。腎臟移植病人的輸血傳遞的肝炎病毒感染跟年齡、性別、輸血史、移植史、血中AST值、血中ALT值、B型肝炎病毒感染或C型肝炎病毒感染無關。結論:本研究顯示輸血傳遞的肝炎病毒感染跟肝臟疾病是不相關的。腎臟移植病人的輸血傳遞的肝炎病毒感染盛行率跟健康檢查者的盛行率是沒差異的。 |
英文摘要 | Object: Many studies have reported the prevalence of transfusion-transmitted virus (TTV) infection in hemodialysis patients but only a few reports have studied the prevalence of TTV infection in renal transplant recipients and none from Taiwan. In this study, we have determined the prevalence of TTV in renal transplant recipients and related its prevalence to history of blood transfusion, serum hepatitis B surface antigen (HBsAg), antibodies to hepatitis C virus (anti-HCV) and serum aminotransferase (AST and ALT) levels in eastern Taiwan. Patients and Methods: Serum samples from 23 renal transplant recipients and a control group of 43 subjects at health examination were studied for TTV viremia using polymerase chain reaction. Results: The proportion of blood transfusions (p<0.001) and HCV infection (p=0.048) were significantly higher in renal transplant recipients. Renal transplant recipients had higher mean levels of serum AST (p=0.013) and ALT (p=0.019) than the control group. The prevalence rare of TTV viremia was not significantly different between renal transplant recipients and the control group (34.8% vs 37.2%). TTV infection was not associated with evident liver disease in renal transplant recipients. There was no statically significant association between TTV infection and age, gender, transfusion history, duration of transplantation, AST level, ALT level, HbsAg or anti-HCV status in renal transplant recipients. Conclusions: These results suggest that TTV infection is not associated with evident liver disease, and the prevalence rare is not different between healthy individuals and renal transplant recipients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。