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題名 | Analysis of Antiretroviral Drugs in Biological Matrices for Therapeutic Drug Monitoring=抗逆轉濾過性病毒藥物在生物模式下之分析應用於藥物治療監測 |
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作者姓名(外文) | Önal, Armağan; | 書刊名 | 藥物食品分析 |
卷期 | 14:2 2006.06[民95.06] |
頁次 | 頁99-119+219 |
分類號 | 412.36 |
關鍵詞 | 藥物治療監測; 蛋白質酶抑制劑; 核苷反轉錄酶抑制劑; 核苷酸反轉錄酶抑制劑; 高效液相層析; Therapeutic drug monitoring; Protease inhibitors; Nucleoside reverse transcriptase inhibitors; Nucleotide reverse transcriptase inhibitors; High performance liquid chromatography; |
語文 | 英文(English) |
中文摘要 | 抗逆轉濾過性病毒藥物在生物模式下之高效液相層析 (HPLC) 分析正被評論於藥物治療監測之用途。對於該類藥品,HPLC為最常被使用的分析方法。液-液萃取、固相萃取及蛋白質沉澱技術均使用於生物檢體之預純化。抗逆轉遞過性病毒藥物可藉由不同的方法來檢測,包括紫外光、螢光、質譜儀及質譜串聯法。這篇綜論顯示,HPLC法在生物模式下可獨立或多重定量檢測抗逆轉溝通性病毒藥物,以作為藥物治療監測之用。 |
英文摘要 | High-performance liquid chromatographic (HPLC) analysis of antiretroviral (ARV) drugs in biological matrices are reviewed for therapeutic drug monitoring purposes. HPLC is the most often used analysis method of these drugs. Liquid-liquid extraction, solid phase extraction and protein precipitation were used for the prepurification of the biological samples. ARV drugs were detected by various detection methods, including ultraviolet, fluorescence, mass spectrometry (MS) and MS/MS. This review shows that HPLC methods allow quantitative determination of antiretroviral drugs, individually or simultaneously in biological matrices for therapeutic drug monitoring purposes. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。