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題名 | Tumor Necrosis Factor-α Gene G-308A and G-238A Polymorphisms are not Associated with Rheumatic Heart Disease in Taiwan=甲型腫瘤壞死因子基因G-308A及G-238A之多型性與風濕性心臟病無相關性 |
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作 者 | 周湘台; 蔡輔仁; | 書刊名 | 中臺灣醫學科學雜誌 |
卷期 | 11:3 民95.09 |
頁次 | 頁149-154 |
分類號 | 415.3162 |
關鍵詞 | 臺灣; 甲型腫瘤壞死因子基因多型性; 風濕性心臟病; Taiwan; TNF-α gene polymorphisms; Rheumatic heart disease; |
語文 | 英文(English) |
中文摘要 | 目的 風濕性心臟病是以慢性發炎過程為其表徵,細胞激素甲型腫瘤壞死因子在慢性發炎反應上擔任重要角色。本研究的目的在探討甲型腫瘤壞死因子基因多型性是否能當作臺灣人風濕性心臟病病患感受性或危險性的標記。 方法 以115位經心臟超音波診斷為風濕性心臟病病患及103位年齡性別相配的正常人為對象。用聚合酶連鎖反應限制酶分析法研究風濕性心臟病患及正常人的甲型腫瘤壞死因子基因G-308A及G-238A之多型性。 結果 風濕性心臟病患及正常人的甲型腫瘤壞死因子基因G-308A及G-238A之多型性基因型及對偶基因頻率分佈並無差異。將風濕性心臟病病患分成二尖瓣疾病及多瓣膜疾病兩組,也未發現兩組間的甲型腫瘤壞死因子基因G-308A及G-238A之多型性基因型及對偶基因頻率分佈有統計學上的差異。 結論 甲型腫瘤壞死因子基因G-308A及G-238A多型性不適合當作臺灣人風濕性心臟病的標記。 |
英文摘要 | Purpose. The aim of this study was to test whether tumor necrosis factor (TNF)-αgene polymorphisms could be used as markers of susceptibility or severity or rheumatic heart disease (RHD) among the Chinese population in Taiwan. Methods. A group of 115 patients with RHD diagnosed by echocardiography, and another group of 103 age and sex-matched normal control subjects were studied. TNF-αgene G-308A and G-238A polymorphisms were identified by polymerase chain reaction-based restriction analysis. Results. There was no significant different in the distribution of genotypes and allelic frequencies of the TNF-αgene G-308A and G-238A polymorphisms between RHD patients and controls. Further categorization of RHD patients into mitral valve disease and combined valve disease subgroups also revealed no statistical difference in these gene polymorphisms when compared with controls. Conclusions. These findings suggest that the TNF-αgene G-308A and G-238A polymorphisms are not suitable genetic markers for RHD in Taiwan Chinese. |
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