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題名 | Levels on Intracellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Children with Henoch-Schönlein Purpura=過敏性紫斑症病童的血清細胞間黏附分子與血管黏附分子的濃度 |
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作者姓名(中文) | 王忴人; 楊謹旭; 林于燦; 江伯倫; | 書刊名 | 微免與感染雜誌 |
卷期 | 39:2 民95.04 |
頁次 | 頁109-113 |
分類號 | 415.62 |
關鍵詞 | 過敏性紫斑症; 血清細胞; 黏附分子; 血管; Henoch-schönlein purpura; Intercellular adhesion molecule-1; Vascular cell adhesion molecule-1; |
語文 | 英文(English) |
英文摘要 | Background and Purpose: Henoch-Schönlein purpura (HSP) is a small vessel vasculitis. Soluble adhesion molecules play a very important role in the immuno-inflammatory reaction of damaged vascular tissues. This study investigated the prognostic and diagnostic potential of soluble intracellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) in HSP. Methods: Serum levels of sICAM-1 and sVCAM-1 were studied in 26 children with HSP. Paired blood samples (during acute and convalescent stages) were collected from 17 of the children and assayed by enzyme-linked immunosorbent assay. Correlations with clinical manifestations were examined. Seventeen healthy children served as controls. Results: Both sICAM-1 and sVCAM-1 were significantly elevated at the acute stage compared with the remission stage of HSP patients versus controls (p=0.006 and p=0.0173, respectively). Conclusions: Although the levels of sICAM-1 and sVCAM-1 were not correlated with the severity of clinical manifestations in HSP, these soluble adhesion molecules may serve as diagnostic markers. |
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