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頁籤選單縮合
題名 | Rifampin-induced Henoch-Schönlein Purpura in Pulmonary Tuberculosis=肺結核使用利肺寧引起過敏性紫斑症 |
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作者姓名(中文) | 王漢彬; 黃瑋琛; 趙載光; 彭萬誠; | 書刊名 | 胸腔醫學 |
卷期 | 26:4 2011.08[民100.08] |
頁次 | 頁219-224 |
分類號 | 418.2219 |
關鍵詞 | 利肺寧; 過敏性紫斑症; 血管炎; Rifampin; Henoch-Schönlein purpura; Vasculitis; |
語文 | 英文(English) |
中文摘要 | 一位53歲男性因為活動性肺結核住院,當給予標準四項抗結核藥物治療時,在皮膚、腎臟和腸胃黏膜產生了罕見且嚴重的血管炎。皮膚和腎臟切片檢查證實是過敏性紫斑症(Henoch-Schönlein purpura)。在利肺寧(rifampin)停用後,皮膚和腸胃道的症狀明顯改善。藉由組織學和藥物再激發反應,證明了利肺寧和過敏性紫斑症的關係。雖然利肺寧引起的過敏性紫斑症機轉不明,但免疫複合物沉積在皮膚和腎臟組織是個很重要的病理發現。當血管炎及相關的症狀都出現時,利肺寧引起的過敏性紫斑症應予以考慮,併同時停用利肺寧。 |
英文摘要 | A 53-year-old man was admitted due to active pulmonary tuberculosis, and, while on standard quadruple anti-tuberculosis therapy, developed a rare severe vasculitis involving the skin, kidney, and gastrointestinal mucosa. Skin and renal biopsies identified Henoch-Schönlein purpura (HSP). The cutaneous and gastrointestinal symptoms improved after rifampin was discontinued. The interaction between rifampin and HSP was confirmed by histology and drug re-challenge. Although the mechanism of rifampin-induced HSP remains unclear, immune complex deposition in the skin and renal tissues are important pathological findings. Once vasculitis and the associated symptoms are present, rifampin-induced HSP should be considered, along with prompt discontinuation of the rifampin. |
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