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題名 | SEN Virus Infection in Patients on Maintenance Hemodialysis in Eastern Taiwan=東臺灣血液透析病人SENV病毒的盛行率 |
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作 者 | 劉作財; 林憲宏; 王豊裕; 羅時燕; 林等義; 胡志棠; 王智賢; 方德昭; 徐邦治; | 書刊名 | 慈濟醫學 |
卷期 | 18:3 民95.06 |
頁次 | 頁179-183+246 |
分類號 | 412.41 |
關鍵詞 | SENV型肝炎病毒; 血液透析; 盛行率; SEN virus; Hemodialysis; Prevalence; |
語文 | 英文(English) |
中文摘要 | 目的:血液透析病人為胖炎感染的高危險族群。本研究目的即探討東臺灣血液透析病人的SENV-D型肝炎及SENV-H型肝炎病毒感染盛行率。病人與方法:研究對象為東臺灣某一血液透析中心119位血液透析病人及43位健康檢查者,抽血萃取病毒DNA再以聚合連鎖反應(polymerase chain reaction)進行SENV-D型肝妖及SENV-H型肝炎病毒的檢查。結果:研究發現東臺灣血液透析病人相對於健康檢查者有較高的輸血率(P<0.0001),C型肝炎病毒感染率(P=0.001)及血中AST值(P=0.049)。SENV肝炎病毒感染率、SENV-D肝炎病毒感染率、SENV-H肝炎病毒感染率在血液透析病人比健康檢查者為低(相對上為10.9% vs 32.6%;4.2% vs 16.3%;7.6% vs 23.4%)。只有一位SENV-D肝炎病毒感染的血液透析病人有C型肝炎病毒感染。SENV-H肝炎病毒感染的血液透析病人不會有C型肝炎病毒感染(P=0.047)。血液透析病人的SENV肝炎病毒感染跟年齡、性別、輸血史、血中AST值、血中ALT值、B型肝炎病毒感染無關。結論:本研究顯示SEN型肝炎病毒感染在東臺灣健康檢替醏較高,相對的,在血液透析病人較低。需要進一步實驗證實其中差異。 |
英文摘要 | Objective: Patients on maintenance hemodialysis have a higher risk of viral hepatitis infection and this study investigates the prevalence of SENV-D and SENV-H viremia among hemodialysis patients in eastern Taiwan. Patients and Methods: Serum samples were obtained from 119 patients attending a hemodialysis center in eastern Taiwan, and from 43 patients undergoing health examinations. These were tested for SENV-D and SENV-H viremia using polymerase chain reaction. Results: The occurrence of blood transfusion (p<0.0001), the frequency of hepatitis C virus (HCV) infection (p=-0.001), and serum AST level (p=0.049) were significantly higher among hemodialysis patients. The prevalence rates of SENV (D and/or H) viremia, SENV-D viremia, SENV-H viremia were lower in hemodialysis patients than in control group (10.9% vs 32.6%; 4.2% vs 16.3%; 7.6% vs 23.4%, respectively). Only one SENV-D (+) hemodialysis patient was confected with HCV. No SENV-H(+) patients was positive for anti-HCV among the hemodialysis patients (P=0.047). There was no Statistically significant association between SENV infection and age of recruitment, gender, transfusion history, AST level, ALT level or hepatitis B surface antigenemia among the hemodialysis patients. Conclusion: There results indicate that SENV infection is a common viral infection in healthy individuals, but, unexpectedly, the frequency of infection among hemodialysis patients in eastern Taiwan was significantly lower than the frequency among healthy individuals. Further studies are therefore needed to resolve this dichotomy. |
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