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頁籤選單縮合
題名 | Proteinuria over 7 G Per Day Predicts Non-diabetic Nephropathy in Type 2 Diabetic Patients=第2型糖尿病的病患若蛋白尿超過每天7克可預測非糖尿病腎病變 |
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作者 | 巫文平; 徐國雄; 鄭志雄; 陳呈旭; 李文欽; 文美卿; 吳明儒; | 書刊名 | 臺灣腎臟醫學會雜誌 |
卷期 | 20:1 民95.03 |
頁次 | 頁22-27+73 |
分類號 | 415.6681 |
關鍵詞 | 糖尿病腎病變; 第2型糖尿病; 蛋白尿; 腎臟切片; 糖尿病視網膜病變; Diabetic nephropathy; Type 2 diabetes mellitus; Proteinuria; Renal biopsy; Diabetic retinopathy; |
語文 | 英文(English) |
中文摘要 | 背景:第四期糖尿病的腎病變以顯著的蛋白尿為其特點,甚至會達到腎病症侯群的程度。但是非糖尿病腎病變在第2型糖尿病的病患上並不罕見。本研究的目的就是要探討第2型糖尿病病患的重度蛋白尿和非糖尿病腎病變的關聯性。材料和方法:我們收集西元1992年5月到西元2004年12月之間於本院接受腎臟切片的第2型糖尿病病患。我們用邏輯回歸的統計方法用來評估最初的每日蛋白尿(DUP)的嚴重程度和非糖尿病腎病變的關聯性。結果:總共有78位第2型糖尿病的病患加入這個研究。平均的年齡是57.0±12.2歲(範圍:33~82歲)。在這些病人之中,41位病患(52.6%)是單純的糖尿病腎病變,11位(14.1%)病患同時有非糖尿病腎病變和糖尿病腎病變,另外26位病患(33.3%)是單純的非糖尿病腎病變。最常見的非糖尿病腎病變是膜性腎病變(16位,43.2%)和IgA腎病變(6位,16.2%)。與有糖尿病腎病變的病患相比,非糖尿病腎病變的病患有較短的糖尿病病史(4.8±4.6比8.1±6.1年)以及較少的糖尿病視網膜病變(43.3%比83.3%)。邏輯回歸分析顯示第2型糖尿病病人若每日蛋白尿大於7克比每日蛋白尿介於1至7克的病患有較高的非糖尿病腎病變發生率(58.8%比30.8%,p<0.05)。結論:我們的研究顯示,每日蛋白尿超過7克在第2型糖尿病的病患,特別是合併無視網膜病變時,可以做為診斷非糖尿病腎病變的一種重要預測因子。膜性腎病變和IgA腎病變是第2型糖尿病病患中最常引起非糖尿病腎病變的原因。 |
英文摘要 | Background: Stage IV diabetic nephropathy (DN) is characterized by overt proteinuria, and even nephritic syndrome. Non-diabetic nephropathy (NDN) is not uncommon in type 2 diabetic patients. The aim of the study is to access the relationship of heavy proteinuria and NDN in type 2 diabetic patients. Material and Methods: Between May 1992 and December 2004, type 2 diabetic patients who received renal biopsy were enrolled. Statistical method of logic regression was used to evaluate the correlation of the level of initial daily urine protein (DUP) and NDN. Result: Overall, 78 type 2 diabetic patients were enrolled. The mean age was 57.0±12.2 years old (range: 33 to 82 years). Of them, 41 (52.6%) patients had isolated DN, 11 (14.1%) patients have both DN and NDN, while another 26 (33.3%) patients had NDN. The most common NDN were membranous glomerulonephropathy (16, 43.2%) and IgA nephropathy (6, 16.2%). Compared to patients with DN, those patients with NDN had significantly shorter duration of diabetes (4.8±4.6 vs 8.1±6.1 years) and lesser retinopathy (43.3% vs 83.3%). The logic regression analysis showed that type 2 diabetic patients with DUP over 7 g had higher incidence of NDN, when compared with patient with DUP between 1 g and 7 g (58.8% vs 30.8%, p<0.05). Conclusion: Our results showed that, DUP over 7 g, especially in patients without diabetic retinopathy, is a strong predictor for the diagnosis of NDN in type 2 diabetic patients. MGN and IgA nephropathy were the most common causes of NDN in type 2 diabetic patients. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。