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題名 | Invasive Fungal Infections in Pediatric Patients with Leukemia: Emphasis on Pulmonary and Dermatological Manifestations=白血病兒童侵襲性黴菌感染:強調肺臟和皮膚的表現 |
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作者 | 王世敏; 楊燿榮; 陳建旭; 林慧真; 齊嘉鈺; 劉清泉; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷期 | 46:3 民94.05-06 |
頁次 | 頁149-155+185 |
分類號 | 415.635 |
關鍵詞 | 侵襲性黴菌感染; 白血病; 念珠菌感染; Disseminated fungal infection; Leukemia; Candidiasis; |
語文 | 英文(English) |
英文摘要 | Patients of hematological malignancies with neutropenia form one of the most susceptible host groups for microbial infection. In this study, we concentrated on the pulmonary and cutaneous manifestations of invasive fun gal infections in leukemic children, aiming to make early diagnosis and intervention. Clinical, laboratory, radiological, and histopathological findings concerning 13 leukemic children who had invasive fun gal infection between 1997 and 2002 were retrospectively reviewed. Seventy-seven percent (10/13) of diagnoses were made by fungal cultures and/or by histopathological evidence from various specimens, four from cutaneous lesions and six from pulmonary tissues. Candidiasis was the most common infection (69%), followed by mucormycosis (15%), fusariosis (8%), and aspergillosis (8%). Three episodes of fungemia (23%) were identified. Lung (69%) and skin (69%) were the two most common sites of disseminated fun gal infections. A premortem diagnosis was documented in 92% of the patients. Pathogens other than Candida albicans (85%) accounted for the great majority of cases. The case-fatality rate was 31% of disseminated fun gal infections. A vigilant assessment of any suspicious lesion by physical and radiological examinations, including a biopsy of the lesions for microbiological and histopathological studies, may provide helpful for early diagnosis of disseminated fun gal infections in leukemic children. |
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