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頁籤選單縮合
題名 | Transient Leukemia in a Case of Mosaic Trisomy 21=拼湊型唐氏症合併暫時性白血病:一病例報告 |
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作者 | 林千微; 陳英堯; 林淑敏; 邱寶琴; 謝凱生; 巫宏博; | 書刊名 | Clinical Neonatology |
卷期 | 5:2 1998.12[民87.12] |
頁次 | 頁30-32 |
分類號 | 417.509 |
關鍵詞 | 唐氏症; 暫時性白血病; Transient leukemia; Mosaic trisomy 21; Congenital leukemia; |
語文 | 英文(English) |
英文摘要 | The incidence of leukemia in Down syndrome is 10 to 20 folds higher than that in the general population. If the leukemia occurs in a newborn, 30% to 50% are transient leukemia and will spontaneously go into remission. We describe here a female neonate who presented with an elevated white blood cell counts, associated with a high percentage of blast cells. A cytochemical stain of the bone marrow revealed properties of acute myeloblastic leukemia, which is rare in childhood. Although the baby had a nearly normal phenotype, chromosome analysis revealed constitutional mosaicism for trisomy 21. Supportive management was given without use of chemotherapeutic agents. Complete remission occurred within 2 months. |
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