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題 名 | 多重抗藥性包氏不動桿菌臨床分離株之分子特性=Molecular Characterization of Clinical Multidrug-resistant Acinetobacter Baumannii Isolates |
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作 者 | 吳敏華; 黃介辰; | 書刊名 | 澄清醫護管理雜誌 |
卷 期 | 2:1 民95.01 |
頁 次 | 頁17-22 |
分類號 | 419.38 |
關鍵詞 | 多重抗藥性包氏不動桿菌; 脈衝電場電泳; 第一類integron; Multidrug-resistant acinetobacter baumannii; MDR-Ab; Pulsed-field gel electrophoresis; PFGE; type 1 integron; |
語 文 | 中文(Chinese) |
中文摘要 | 包氏不動桿菌(Acinetobacterbauman-nii) ,是革蘭氏陰性之球桿菌,為一常見的環境微生物,亦是人類皮膚與黏膜上的正常菌叢之一,近年來卻因其抗藥性所帶來之問題趨嚴重而成為院內感染的重要病原菌,且已陸續出現對多種抗生素具抗藥性的菌林(Multidrug-resist-ant Acinetobacter baumannii ;MDR-Ab)。近年來在台灣也頓頻出現MDR-Ab,因而喚起圈內外對包氏不動桿菌抗藥性之問題的注意與關切。 |
英文摘要 | Purpose: Acinetobacter baumannii, a coccobacilli, is a common environmental microbe as well as one of the normal floras on the skin and mucous membranes of human bodies. Due to the serious problems resulted from drug resistance of such germ for the past few years, it becomes a critica1 pathogenic bacteria causing infections in the hospitals. Multidrug-resistant Acinetobacter baumannii (MDR-Ab), a strain that resists multidrug, has appeared. Recent1y, MDR-Ab was also discovered in Taiwan very fre quent1y. Therefore, awareness of such problems and finding out proper solutions have become critical issues both in our country and overseas. Materials and Methods: Based on the epidemic information on clinica1 MDR-Ab strains collected by a regional hospitallocated in centra1 Taiwan.. In addition, the possi- bility of whether the drug-resistant gene diffuses among strains in a horizontal way is explored. The twelve imipenem-resistant Acinetobacter baumannii strains used in this study were isolated from a regional hospital located in central Taiwan from June 1, 2002 to May 31 ,2003. Theywere further conducted an antibiotic susceptibility test by the Disk diffusion experiment and VITEK 2 Advance Expert System to explore the phenotype of these twelve mu1tidrug-resistant strains. Furthermore, the 'BioNumerics" ana1ysis software was applied after PFGE to compare and locate the genetic/phylogenesis relationship among the strains. Besides, those Integrase genes of Integron, a horizontal diffusion platform, were analyzed with the PCR method. Results:The PFGE result indicated these twelve MDR-Ab strains could be divided into two clusters (Cluster A & Cluster B). And, there was a type 1 Integrase gene of about 160-bp fragment existed in all these twelve MDR-Ab strains. Conclusion:There was a type 1 Integrase gene of about 160-bp fragment existed in all these twelve MDR-Ab strains. So,all have type 1 Integron..We know integron,a genetic element which facilitates gene dissemination among bacteria of different species and perhaps genera. The result revealed the possibility of horizontal transfer of the drug-resistant genes of all these twelve MDR-Ab strains. |
本系統中英文摘要資訊取自各篇刊載內容。