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題名 | Gabapentin Therapy for Persistent Hiccups and Central Post-Stroke Pain in a Lateral Medullary Infarction--Two Case Reports and Literature Review=以Gabapentin治療外側延腦梗塞引起的持續性打嗝及中樞型中風後疼痛--二病例報告及文獻回顧 |
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作者 | 梁啟源; 蔡坤維; 許明欽; | 書刊名 | 慈濟醫學 |
卷期 | 17:5 民94.10 |
頁次 | 頁365-368+386 |
分類號 | 415.922 |
關鍵詞 | 打嗝; 中樞型中風後疼痛; 外側延腦梗塞; Hiccups; Gabapentin; Central post-stroke pain; Lateral medullary infarction; |
語文 | 英文(English) |
中文摘要 | 打嗝與疼痛二者均是眾所周知,卻常被忽略的中風併發症。中風病人持續性打嗝可能導致嚴重甚至於致命的後遺症,例如吸入性肺炎,營養不良及呼吸停止。我們報告兩病例均是由於外側延腦梗塞引起的持續性打嗝。我們嘗試以Gabapentin治療,兩位病人的持續性打嗝均快速有效緩解。第二位病例後來產生中樞型中風後疼痛。中樞型中風後疼痛特別盛行於外側延腦梗塞,且傳統藥物治療僅具部分療效。我們亦嚐試使用Gabapentin治療,結果用藥兩周後疼痛程度明顯降低。此報告對於外側延腦梗塞引起的持續性打嗝及中樞型中風後疼痛,以Gabapentin治療似乎有其潛在的優勢。 |
英文摘要 | Hiccups and pain are well known although often overlooked complications of a stroke. Persistent hiccups in patients with a stroke can be associated with potentially fatal consequences, such as aspiration pneumonia, malnutrition, and respiratory arrest. We present 2 patients who suffered from persistent hiccups due to a lateral medullary infarction. We treated them with gabapentin, and both responded quite promptly. Central post-stoke pain (CPSP) is particularly prevalent after a lateral medullary infarction, and only partially responds to conventional treatment. One of the 2 patients had CPSP and failed to respond to a variety of oral analgesics; but within 2 weeks of the inception of gabapentin therapy, his average pain intensity was significantly reduced. This report suggests a potential advantage of gabapentin in the treatment of persistent hiccups and CPSP in patients with a lateral medulary infarction. |
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