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| 題 名 | Feminizing Adrenocortical Adenoma Presenting as Heterosexual Precocious Puberty: Report of One Case=腎上腺雌性激素瘤合併異性性早熟:一病例報告 |
|---|---|
| 作 者 | 蕭惠彬; 趙美琴; 林釗佑; 陳秀玲; 邱世欣; 陳百薰; | 書刊名 | 臺灣兒科醫學會雜誌 |
| 卷 期 | 46:2 民94.03-04 |
| 頁 次 | 頁97-100+121 |
| 分類號 | 415.934 |
| 關鍵詞 | 性早熟; 腎上腺瘤; 男性女乳症; 女性化; Precocious puberty; Adrenal adenoma; Gynecomastia; Feminizing; |
| 語 文 | 英文(English) |
| 英文摘要 | We report on a case of a 2 2/12-year-old boy with heterosexual precocious puberty secondary to a feminizing adrenocortical adenoma. The boy, with no previous history of disease or treatment, presented with bilateral gynecomastia and pubic hair development (Tanner Ⅲ breasts and Tanner Ⅱ pubic hair). Plasma estradiol and testosterone were 410.9 pg/ml and 126.2 ng/dl respectively. Basal plasma LH and FSH levels were within the normal range. Bolus i.v. injection of GnRH showed unresponsiveness of LH and FSH. Abdominal echography and abdominal magnetic resonance imaging revealed a well-defined mass at the left suprarenal region (measuring 4.0×2.7×3.6 cm in size). After removal of the adrenal tumor, the estradiol and testosterone levels fell to normal in 2 weeks. The gynecomastia and pubic hair regressed with time. The pathology of the tumor showed compact pattern with polygonal cells containing moderate eosinophilic cytoplasm without mitotic figure. These findings were consistent with an adrenocortical adenoma secreting estradiol and testosterone as the cause of the patient's heterosexual precocious puberty. |
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