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題名 | Antioxidant and Myocardial Ischemia: Reperfusion Injuries=抗氧化劑與心肌缺血再灌流傷害 |
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作者 | 陳君侃; 周淑娥; | 書刊名 | 長庚醫學 |
卷期 | 28:6 2005.06[民94.06] |
頁次 | 頁369-377 |
分類號 | 418.1 |
關鍵詞 | 自由基; 缺血再灌流; 心肌損傷; 抗氧化劑; Polyphenolics; ROS; Infarction; |
語文 | 英文(English) |
中文摘要 | 動物實驗明顯指出,恢復血流是降低缺氧心臟心肌損傷的先決要件。但是各種缺血再灌流的研究指出,缺氧的心臟恢復流血時,往往伴隨著明顯的心肌功能上和結構上的損傷;包括心律不整,細胞傷害致胞內蛋白釋出,及收縮功能異常等。這些變化被認為是心臟再灌流時引起的二度傷害。由於再灌流時會伴隨著激烈的自由基產生,故一般認為再灌流時的心肌二度傷害,是因為氧化壓力造成。細胞內許多重要的生化活動受到自由基及細胞氧化還原狀態的調節,氧化還原狀態的失衡,是引起細胞功能異常的重要原因之一。唯利用抗氧化劑治療缺血再灌流傷害的研究,各方的結果並不一致,且以負面的結果居多。故抗氧化劑治療的臨床利用,仍有待進一步研究。 |
英文摘要 | Animal studies have demonstrated that restoration of blood flow to severely ischemic myocardium is a prerequisite for myocardial salvage. However, it has been shown that the restoration of blood flow to ischemic myocardium may be associated with deleterious changes of the myocardium, including arrhythmias, enzyme release, and contractile dysfunction. These changes were considered to be additional injuries to the myocardium manifested at the time of reperfusion. The reperfusion was accompanied by a burst of oxygen free radical generation and their role as main mediators of the reperfusion injury have been well accepted. Reactive oxygen species (ROS) and cellular redox status regulate many important cellular activities. The role of antioxidant as a therapy for reperfusion injury has thus been tried with mixed and mostly negative results. Further studies are needed if the antioxidant therapies for ischemia reperfusion injury were to be effective. |
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