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題名 | An Open Study of Inactivated Hepatitis A Vaccine (VAQTA) in Taiwanese Healthy Adult Volunteers: Safety, Tolerability, and Immunogenicity=非活化性A型肝炎疫苗(VAQTA)在臺灣成人之安全性與免疫性研究 |
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作者 | 楊靖瑩; 呂俊毅; 邵蓓嵐; 王崇怡; 吳宗儒; 李慶雲; 黃立民; | 書刊名 | 微免與感染雜誌 |
卷期 | 37:4 2004.08[民93.08] |
頁次 | 頁216-218 |
分類號 | 414.82 |
關鍵詞 | 非活化性; A型肝炎; 疫苗; 安全性; 免疫性; Hepatitis A; Hepatitis A antibodies; Inactivated vaccine; Toxicity; |
語文 | 英文(English) |
英文摘要 | The safety, tolerability and immunogenicity of inactivated hepatitis A vaccine (VAQTA, Merck and Co. Inc., West Point, PA, USA) were investigated in 28 seronegative healthy adult volunteers. The age range was 25-35 years, and the mean age was 29 years. Two doses of the vaccine, each containing 50 U of hepatitis A virus antigen, were administered into the deltoid region 24 weeks apart. No serious vaccine-related adverse reactions were reported. Four weeks after the first dose, the geometric mean titer (GMT) was 150 mIU/mL, and the seroconversion rate was 100%. Twenty eight weeks after the first dose (4 weeks following the second dose), the GMT was 4576 mIU/mL. This study demonstrated that VAQTA is safe and highly immunogenic in healthy young adults in Taiwan. |
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