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題 名 | Hyposensitization Therapy Reduced Exhaled Nitric Oxide in Asthmatic Children with Corticosteroid Dependency=減敏治療對類固醇依賴性氣喘兒童吐氣一氧化氮之影響 |
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作 者 | 洪志興; 李明勇; 蔡易晉; 錢新南; 楊崑德; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷 期 | 45:2 民93.03-04 |
頁 次 | 頁89-93 |
分類號 | 415.425 |
關鍵詞 | 減敏治療; 類固醇依賴; 氣喘; Exhaled nitric oxide; Asthma; Hyposensitization therapy; |
語 文 | 英文(English) |
中文摘要 | 氣喘是一種呼吸道發炎疾病。對於氣喘兒童而言,測量尖峰吐氣流量(PEFR),只能得知氣道之阻塞程度,無法得知呼吸發炎程度。偵測吐氣一氧化氮是一種簡單的方法來得知呼吸道發炎情形。減敏治療是治療兒童氣喘的方法之一,尤其是對於類固醇依賴之氣喘兒童。施予減敏治療十個月,並於每月偵測其吐氣一氧化氮濃度、尖峰吐氣流量及氣喘指數,我們發現在治療病童四個月後,即可看到吐氣一氧化氮濃度達到統計學意義的下降(39.89±21.13 ppb;p<0.05),在治療病童五個月後,即可看到尖峰吐氣流量及氣喘指數達到統計學意義的改善。吐氣一氧化氮濃度下降程度和尖峰吐氣流量改善程度成正比。偵測吐氣一氧化氮濃度可當作減敏治療改善氣順情形的一種指標。 |
英文摘要 | Measurement of exhaled nitric oxide (FeNO) is a simple and noninvasive method for assessment of airway inflammation severity in asthmatic patients. The aim of this study was to investigate whether hyposensitization with extracts of Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) could decrease airway inflammation as determined by FeNO levels. Ten asthmatic children with corticosteroid dependency were recruited for the study. Eight subjects completed a ten months mite hyposensitization regimen. FeNO concentrations, asthma symptom scores and peak expiratory flow rates (PEFR) were measured monthly before and after treatment. FeNO levels from asthmatic patients were found to be higher before treatment (65.34±31.63 ppb). FeNO levels fell significantly after four months’ treatment (39.89 ±21.13 ppb; p<0.05). PEFR increased significantly five months after hyposensitization treatment (214.38 ±49.38vs 251.25±28.00; p<0.05). Asthma symptom scores decreased 5 months after hyposensitization treatment (6.84±1.22vs 5.80±0.67, p<0.05). Hyposensitization with extracts of Der p and Der f appears to improve clinical symptoms and reduce airway inflammation as determined by FeNO concentrations in children with mite allergy asthma. |
本系統中英文摘要資訊取自各篇刊載內容。