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頁籤選單縮合
題名 | Comparison of the Effects of "Hot" and "Cold" Chinese Medicinal Plants on the Production of Inflammatory Mediators by RAW 264.7 Cells=熱性與寒性中藥對細胞發炎介質生成之影響 |
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作者 | 何素珍; 蔡帛蓉; | 書刊名 | 藥物食品分析 |
卷期 | 12:2 2004.06[民93.06] |
頁次 | 頁120-127+195 |
分類號 | 414.33 |
關鍵詞 | 黃連; 黃芩; 乾薑; 肉桂; 前列腺素E[feaf]; 一氧化氮; Coptis chinensis; Scutellaria baicalensis; Zingiber officinale; Cinnamomum cassia; Prostaglandin E[feaf]nitric oxide; |
語文 | 英文(English) |
中文摘要 | 溫熱與寒涼平衡機制除了作為中醫治療上一個很重要的原則外,也被東亞地區居民廣為應用在食物的選擇上。已有研究指出熱性食物能促進細胞前列腺素E2的分泌,而寒性食物則對誘發型前列腺素E2的生成具有抑制效應。本研究還取四種中藥並比較各種中藥的溫熱、寒涼特性對細胞發炎介質生成的影響。寒性藥材-黃連、黃苓及熱性藥材乾薑、肉桂以熱水萃取後,分別處理巨噬細胞RAW264.7,並分析在有、無脂多醣 (lipopolysaccharide,LPS) 共兩處理下,發炎介質前列腺素E2 (prostaglandin E2) 及一氧化氮 (nitric oxide) 的生成量。與先前研究一致,熱性藥材-乾薑及肉桂,在無LPS的共同作用下,具有誘發細胞表現環氧化酶-2 (cyclooxygenase-2,COX-2) 及生成前列腺素E2的能力;寒性藥材-黃連與黃苓則會抑制LPS所誘發的環氧化酶-2的蛋白質表現及前列腺素E2的生成。四種中藥材對LPS所誘發的一氧化氮的生成及iNOS的蛋白質表現均具有抑制效應。綜合上述,中藥的寒性或熱性會造成環氧化酶-2蛋白質表現上的差異,推測環氧化時主的表現可能是決定中藥材熱性或寒性的依據,值得進一步分析確認。 |
英文摘要 | The hot/cold balance system plays an important therapeutic role in traditional Chinese medicine and is applied in food selection by East Asians. Foods traditionally considered "Hot" have been demonstrated to have the ability to enhance basal prostaglandin E2 production. Conversely, foods considered "Cold" can suppress prostaglandin E2 production in lipopolysaccharide (LPS)-stimulated cells. Therefore, this study attempted to further confirm the previous hypotheses by selecting four Chinese medicinal plants and comparing their natural hot or cold characteristic influences on the production of inflammatory mediators. Herbs traditionally regarded as hot (Coptis chinensis and Scutellaria baicalensis) or cold (Zingiber officinale and Cinnamomum cassia) were extracted with hot water and applied to RAW 264.7 cells in the presence or absence of LPS. Supporting the previous hypothesis, hot water extracts from the "Hot-herbs", Zingiber officinale and Cinnamomum cassia, induced PGE2 production and COX-2 expression by unactivated cells. In contrast, LPS-induced PGE2 production and COX-2 expression was inhibited dose-dependently by hot water extracts of the "cold-herbs", Coptis chinensis and Scutellaria Baicalensis. All of the subject herbs had a strict inhibitory effect on NO production and iNOS expression. These results implied that COX-2 but not iNOS expression might serve as an indicator of hotness or coldness of medicinal plants. |
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