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題名 | Common Repeat Sequences in Bacterial Genomes=細菌基因體之共同重覆序列 |
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作者 | 張祐誠; 張傳雄; | 書刊名 | Journal of Medical and Biological Engineering |
卷期 | 23:2 2003.06[民92.06] |
頁次 | 頁65-72 |
分類號 | 369.4 |
關鍵詞 | 細菌基因體; 重覆序列; Bacterial genome; Repeat sequence; |
語文 | 英文(English) |
中文摘要 | 重覆序列在細菌基因體內廣泛地出現。然而,大部份重覆序列的詳細功能和運作機制卻仍然是未知的。我們探討了在58個已被完整定序的細菌基因體(包含了60個染色體序列及22個質體序列)之中出現的四種重覆序列。對每一個細菌基因體序列,計算其在數量上及長度上的重覆序列密度,並加以比較。同時也偵測在四種重覆序列中可能出現的共同重覆序列。結果顯示大部份的染色體序列中含有重覆序列,而大部份的質體序列中則不含有重覆序列。重覆序列的密度與細菌的現行分類方式及基因大小均不相關。只有反向互補的重覆序列會被大多數的細菌基因體所共有。這四種重覆序列可能有不同的功能,演化方式及運作機制。為了進一步的研究,我們認為發展結合統計學及每種細菌本身的生物學的新研究方法是必要的。 |
英文摘要 | Repeat sequences are widely appearing in bacterial genomes. However, detailed functions and mechanisms of most repeats are still unknown. We explored four types of repeats in 58 fully sequenced bacterial genomes, including 60 chromosomal and 22 plasmid sequences. For each bacterial genome sequence, the repeat density in number and in length were both calculated and compared, and potential common repeats of four repeat types were also recognized. The results showed most chromosomal sequences contain repeat sequences and a large number of plasmid sequences do not have repeat sequences. The density of repeats is not correlated with either the current taxonomy or the genome size of bacteria. Only the reverse complement repeats are common in most bacterial genomes. The four types of repeats might be different in terms of functions, evolutions and mechanisms. For further investigations, the development of a new methodology with combined statistical analysis and detailed biological knowledge of each bacterial organism will be needed. |
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