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題 名 | Effects of Nonsteroidal Anti-Inflammatory Drugs on Transforming Growth Factor-β Expression and Bioactivity in Rat Osteoblast-Enriched Cultures=非類固醇消炎藥物對大鼠成骨細胞之乙型轉型生長因子之表現與活性之影響 |
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作 者 | 張瑞根; 莊麗月; 何美泠; 王國照; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 19:6 2003.06[民92.06] |
頁 次 | 頁278-288 |
分類號 | 418.224 |
關鍵詞 | 非類固醇消炎藥物; 前列腺素; 成骨細胞; 乙型轉型生長因子; Nonsteroidal anti-inflammatory drugs; Prostaglandins; Osteoblasts; Transforming growth factor-β; |
語 文 | 英文(English) |
中文摘要 | The Kaohsiung Journal of Medical Sciences Shortcut to this page: http://ajws.elsevier.com/ajws3/switch.asp?journal_issn=1607-551X Copyright � 2009 Elsevier. All rights reserved. Volume 19 � Issue 6 � June 2003 RSS feeds | E-mail this article Volume 19, Issue 6, June 2003, Pages 278 - 288 Effects of Nonsteroidal Anti-inflammatory Drugs on Transforming Growth Factor-b Expression and Bioactivity in Rat Osteoblast-enriched Cultures Original Articles Je-Ken Chang, Lea-Yea Chuang, Mei-Ling Ho, and Gwo-Jaw Wang Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to suppress bone remodeling in normal and repaired bones. Our previous results indicated that ketorolac and indomethacin suppressed proliferation, stimulated early differentiation, and induced apoptosis in cultured osteoblasts. Transforming growth factor-beta (TGF-beta) has been reported to enhance proliferation, suppress differentiation, and prevent apoptosis in osteoblasts. We proposed that one pathway of NSAID effects on osteoblast function might be through inhibition of the expression and/or bioactivity of TGF-beta in osteoblasts. We tested the effects of ketorolac and indomethacin on the expression of TGF-beta1 mRNA and protein and the bioactivity of TGF-beta in osteoblast-enriched cultures derived from fetal calvaria. The effects of prostaglandin E1 (PGE1) and PGE2 on TGF-beta expression and bioactivity were also examined in order to understand more about the role of prostaglandins in osteoblast function. Simultaneously, we estimated whether these NSAID effects on osteoblasts were prostaglandin-related. The results showed that 24-hour treatments with both PGEs and theoretic therapeutic concentrations of ketorolac and indomethacin had no significant effects on the levels of either transcription or translation of TGF-beta or the post-translational function of TGF-beta in osteoblasts. These results suggest that NSAIDs do not affect osteoblast function through changes in TGF-beta action in osteoblasts. 研究報告曾指出非類固醇消炎藥(NSAIDs)會抑制正常骨及修復骨之骨重塑作用。我們過去的研究結果發現 ketorolac 和 indomethacin 對培養之成骨細胞有抑制增殖、刺激早期的分化作用以及引導凋亡的作用。研究報告曾指出乙型轉型生長因子(TGF-beta)會促進成骨細胞之增殖,抑制分化及預防凋亡之作用。因此,我們假設 NSAIDs 對成骨細胞功能之影響其中之一路徑,可能是抑制 TGF-beta 之表現或其生物活性而造成。為測試此一假設,我們測定 ketorolac 與 indomethacin 對取自大鼠頭顱骨之成骨細胞的 TGF-beta1 mRNA 與蛋白質之表現以及 TGF-beta 之生物活性之影響。我們並且測定前列腺素 E1(PGE1) 和 PGE2 對 TGF-beta 之表現與活性之影響,以便瞭解更多有關 PGs 在成骨細胞所扮演的角色。同時我們也評估 NSAIDs 的作用是否透過 PG 的途徑而產生。結果顯示處理 PGEs 和理論之治療濃度之 ketorolac 和 indomethacin 24 小時後並無顯著影響 TGF-beta 之轉錄、轉譯以及轉譯之後的功能。這些結果建議 NSAIDs 對成骨細胞功能之影響可能不是透過影響 TGF-beta 的作用使然。 |
英文摘要 | Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to suppress bone remodeling in normal and repaired bones. Our previous results indicated that ketorolac and indomethacin suppressed proliferation, stimulated early differentiation, and induced apoptosis in cultured osteoblasts. Transforming growth factor-beta (TGF-beta) has been reported to enhance proliferation, suppress differentiation, and prevent apoptosis in osteoblasts. We proposed that one pathway of NSAID effects on osteoblast function might be through inhibition of the expression and/or bioactivity of TGF-beta in osteoblasts. We tested the effects of ketorolac and indomethacin on the expression of TGF-beta1 mRNA and protein and the bioactivity of TGF-beta in osteoblast-enriched cultures derived from fetal calvaria. The effects of prostaglandin E1 (PGE1) and PGE2 on TGF-beta expression and bioactivity were also examined in order to understand more about the role of prostaglandins in osteoblast function. Simultaneously, we estimated whether these NSAID effects on osteoblasts were prostaglandin-related. The results showed that 24-hour treatments with both PGEs and theoretic therapeutic concentrations of ketorolac and indomethacin had no significant effects on the levels of either transcription or translation of TGF-beta or the post-translational function of TGF-beta in osteoblasts. These results suggest that NSAIDs do not affect osteoblast function through changes in TGF-beta action in osteoblasts. |
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