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題 名 | 壯骨一號對停經後婦女骨代謝指標之研究=The Effect of CK-1 on Bone Biochemical Markers in Postmenopausal Women |
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作 者 | 張恆鴻; | 書刊名 | 中醫藥年報 |
卷 期 | 17:2 1999.05[民88.05] |
頁 次 | 頁91-106 |
分類號 | 413.61 |
關鍵詞 | 壯骨一號; 成骨細胞指標; 破骨細胞指標; CK-1; Bone formation marker; Bone resorption marker; |
語 文 | 中文(Chinese) |
中文摘要 | 停經後婦女是骨質缺乏、骨質疏鬆症的高危險群,婦女在停經後,骨頭的代謝率會變快,因而加速骨質快速流失。傳統中醫理論認為「腎主骨」,年老腎衰與骨質之衰減應有密切關係,但此等相關准從未經過臨床之測量,近年來雖有報告顯示補腎方藥對骨質有所幫助,但尚無對骨代謝變化有客觀之評估。本項研究以DEXA(dialenergy x-ray absoptiometry)篩選骨密度低於正常人2.5個標準差之停經後婦女,並進行中醫辨症,同時與骨密度正常之停經後婦女,比較腎虛証與骨質疏鬆症之相關性;並將所有患者分別予以補腎藥壯骨一號或雌激素治療,於治療後於每3個月測定其血中成骨細胞指標及尿液中破骨細胞指標之活性,觀察中西藥物對骨代謝指標之影響,以評估療效。結果顯示:停經後婦女屬腎虛體質者,與是否容易罹患骨質疏鬆症具有相關的趨勢,但未達統計上的顯著差異;中藥壯骨一號對停經後婦女的破骨細胞指標(DPD)具有抑制的作用,對成骨細胞指標(BAP)則無明顯影響。 |
英文摘要 | Postmenopausal women are a high risk group of osteopenia and osteoporosis, because their bone turn-over rates become rapidly and that is associated with increased bone loss. According to the traditional theory of Chinese Medicine: "The kidney govern the bone", so that there should be close relationship between with kidney-vacuity syndrome and bone decay. However the association has never been declared in clinical complete measurements. Although recent reports have revealed Chinese kidneysupplement drug is some helpful to bone mineral mass, they have not yet objective evaluation of bone metabolism. Postmenopausal women with normal bone mineral density (BMD) and with lower than 2.5 SD of normal BMD by DEXA (dual energy x-ray absorptiometry) were enrolled in this study. They were classified by Chinese Medicine Syndrome Criteria and the association between Kidneyvacuity syndrome and osteoporosis were studied. We had treated all above patients by either CK-I or estrogen and estimated the activities of serum bone formation marker and urinary bone resorption marker every 3 months after starring treatment. We had observed the effect of both drug on bone metabolism and evaluated their effect. The result showed that there was no significant difference between kidney-vacuity group and non-kidney-vacuity group in their rate of osteoporosis. The CK-I of Chinese medicine had suppression effect on urinary bone resorption marker (deoxypyridinoline). |
本系統中英文摘要資訊取自各篇刊載內容。