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題名 | Aflatoxin-Induced Hepatocarcinogenesis: Epidemiological Evidence and Mechanistic Considerations=黃麴毒素致肝細胞癌:流行病學證據與致癌機制之探討 |
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作者 | 孫建安; 陳建仁; | 書刊名 | Journal of Medical Sciences |
卷期 | 23:6 2003.12[民92.12] |
頁次 | 頁311-318 |
分類號 | 415.536 |
關鍵詞 | 黃麴毒素; 肝細胞癌; Aflatoxin; Biomarker; Hepatocellular carcinoma; p53 mutation; |
語文 | 英文(English) |
英文摘要 | Primary hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Hepatitis B virus (HBV) and aflatoxin exposure represent the main risk factors for the development of HCC in areas endemic for liver cancer. The recently developed individual biological markers of aflatoxin exposure permit a better quantitative estimation of aflatoxin exposure in different populations of the world. Research into the association between aflatoxin and HCC represents one of the most complete examples of the use of biomarkers to assist in the identifications of risk factors associated with carcinogensis in humans. This paper reviews the data that have accumulated from both traditional and molecular epidemiological studies implicating aflatoxin exposure as an important risk factor in the etiology of HCC. In addition, epidemiological and experimental data are examined regarding the synergistic effects of aflatoxin exposure and HBV on HCC formation and the predominance of one hotspot GC→TA transversion in the p53 gene of aflatoxin-induced hepatocarcinogenesis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。