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題 名 | RUNX3 Hypermethylation in Remnant Gastric Cancer: A Preliminary Report=RUNX3 Promotor Hypermethylation於殘胃癌的表現:早期報告 |
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作 者 | 歐陽資明; 周燕輝; 李中偉; 李進成; | 書刊名 | 臺灣外科醫學會雜誌 |
卷 期 | 36:6 民92.11-12 |
頁 次 | 頁274-278 |
分類號 | 415.114 |
關鍵詞 | 殘胃癌; 抑癌基因; RUNX3; Remnant gastric cancer; |
語 文 | 英文(English) |
中文摘要 | RUNX3是一種新世代的抑癌基因。它被發現與胃的粕膜細胞增生有密切的關係。如果RuNx3抑癌基因發生突變,在動物實驗中可以發現胃黏膜細胞有異常增生的現象。RUNX3抑癌基因發生突變,主要是在其Promotor位置發Hypermethylation。我們回朔性的將11位殘冑癌的病患的手術標本做DNA分析,發現其中確實有RUNX3 Promotor Hypermethy-lation的現象。 |
英文摘要 | RUNX3 (PEBP2aIphaC/CBFA3/AML2) is a transcription factor downstream of the TGF p signaling pathway. RUNX3 knocked-out mice showed hyperproliferation and hyperplasia in gastric epithelium. Lack of RUNX 3 expression, partly due to promoter hypermethylation, had been associated with the human gastric cancers. This study is aimed to evaluate the relationship between RUNX3 expression and human remnant gastric cancer. The methylation status of RUNX 3 promoter in human remnant gastric cancer was investigated by methylation-specific restriction enzyme digestion and PCR amplification. We retrospectively reviewed the surgically removed specimen of eleven cases of remnant gastric cancer. Hypermethylation of RUNX 3 in its promoter region was found in the tumor tissues of all eleven cases. Further studies are required to clarify the direct relationship between RUNX3 and remnant gastric cancer. |
本系統中英文摘要資訊取自各篇刊載內容。