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題 名 | Primary Biliary Cirrhosis with Negative Anti-Mitochondrial Antibody: A Case Report=血清抗粒腺體抗體陰性之原發性膽道性肝硬化:一病例報告 |
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作 者 | 蔡元銘; 周楠華; 鄭斌男; 張定宗; | 書刊名 | 慈濟醫學 |
卷 期 | 15:5 2003.10[民92.10] |
頁 次 | 頁347-351 |
分類號 | 415.534 |
關鍵詞 | 抗粒腺體抗體陰性原發性膽道性肝硬化; 肝硬化; 原發性膽道性肝硬化; Cirrhosis; Primary biliary cirrhosis; Anti-mitochondrial antibody; |
語 文 | 英文(English) |
中文摘要 | 原發性膽道性肝硬化以疲倦、發癢、肝腫大、黃疸及具有抗粒線體抗體等為特色。我們發表一個具 有抗粒線體抗體陰性的55歲女性病人,她具不正常的肝功能,尤其是代表膽汁滯留的鹼性磷酸酵素和血清麩胺胺醯轉移。腹部超音波發現有肝硬化,但院無任何膽道擴張。病理組織切片發有膽管的漏失,門脈區有淋巴球浸潤且有肉芽腫組織形成。確切診斷是經過病理組織切片證實及升高的免疫球蛋白和抗核抗體。因此,她開始接受膽鹽治療。十年之後,肝功能指數被控制住且回復到接近正常的濃度。 |
英文摘要 | Primary biliary crrhosis (PCB) is characterized by fatigue, pruritus, or hepatomegaly, and by the presence of anti-mitochondrial antibody (AMA). We report on a 55-year-old female with PBC, but who was negative for AMA. She had elevated liver biochemistry, especially alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), which in the indicate cholestasis. Abdominal sonography revealed liver cirrhosis with no evidence of biliary tract dilatioation. Liver pathology showed loss of the bile duct, lymphocyte infiltration within portal areas, and granuloma formation. The diagnosis of PBC was confirmed by pathologic findings in addition to immunoglobulin (Ig) M and antinuclear antibody (ANA). She received oral ursodeoxycholic acid at a dosage of 12mg/kg/day. After 10 years of treatment, live function has been well controlled, and she has nearly normal liver biochemical tests. |
本系統中英文摘要資訊取自各篇刊載內容。