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題名 | Efficacy of Nebulized Budesonide in Hospitalized Infants and Children Younger than 24 Months with Bronchiolitis=以氣霧式budesonide治療住院嬰幼兒之急性細支氣管炎 |
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作 者 | 趙麗珠; 林應然; 吳維峰; 黃富源; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷期 | 44:6 民92.11-12 |
頁次 | 頁332-335 |
分類號 | 418.263 |
關鍵詞 | 氣霧式budesonide; 急性細支氣管炎; Nebulized budesonide; Bronchiolitis; Infant; Young child; |
語文 | 英文(English) |
中文摘要 | 爲瞭解氣霧式budesonide對嬰幼兒喘鳴病人之臨床療效,我們針對73位年齡小於24個月,因急性喘鳴而住院的病例,嘗試以氣霧式budesonide(1mg/2ml)進行臨床研究。我們將病人分爲四組,第Ⅰ組有18人,爲年齡小於12個月,投與budesonide及2ml isotonic sodium chloride;第Ⅱ組有18人,爲年齡小於12個月,只投於4ml isotonic sodium chlorie;第Ⅲ組有16人,爲年齡介於12與24個月,投與terbutaline(5mg/2ml)及2ml isotonic sodium chlorede,第Ⅳ組有21人,爲年齡介於12與24個月,投與budesonide及terbutaline。我們在治療前後以呼吸速率,喘鳴分數(wheezing score),發紺分數(cyanosis score),及使用副肌肉分數(accessory muscle score)做爲評估。結果顯示氣霧式budesonide無論在年齡小於12個月或大於12個月之性院急性細支氣管炎病人的治療效果並無統計學上之差異。所以治療上還需傳統保守療法,給予濕冷氧氣的環境以減緩低血氧及呼吸過速所造成之水分流失。 |
英文摘要 | To evaluate the effect of nebulized budesonide on acute, young, wheezing patients, a total of 73 patients, aged below 24 months, who were hospitalized due to bronchiolitis were randomly enrolled into this study according to age. They were divided into four groups and treated with four kinds of nebulized solutions. Group I consisted of 18 patients under 12 months old who were treated with budesonide (1mg/2ml) diluted with 2 ml isotonic sodium chloride. Group II consisted of 18 patients under 12 months old who were treated with 4ml isotonic sodium chloride. Group III included 16 patients between 12 and 24 months old who were treated with terbutaline (5mg/2ml) diluted with 2ml isotonic sodium chloride. Group IV included 21 patients between 12 and 24 months old who were treated with budesonide (1mg/2ml) and terbutaline (5mg/2ml). Clinical data on respiratory rate, wheezing score, cyanosis score and accessory respiratory muscle utilization score were recorded in all patients before and after treatment throughout the entire hospitalization. The results of this study showed no benefits from nebulized budesonide in infants with bronchiolitis either younger than 12 months old or between 12 and 24 months of age. The duration of admission also showed no significant differences among the groups. |
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