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題 名 | Effects of Maternal Nicotine Exposure on Branching Morphogenesis of Mouse Fetal Lung: In Vivo and in Vitro Studies=母體內尼古丁暴露對老鼠胎兒呼吸道分支形態學之影響--體內與體外動物實驗 |
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作 者 | 夏紹軒; 陳淑卿; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷 期 | 44:3 民92.05-06 |
頁 次 | 頁150-154+183 |
分類號 | 417.343 |
關鍵詞 | 尼古丁; 新生兒型呼吸窘迫症候群; 呼吸道分支形態學; Nicotine; Airway branching morphogenesis; Neonatal respiratory distress syndrome; |
語 文 | 英文(English) |
中文摘要 | 某些流行病學之研究指出,吸煙母親所產出之早產兒較不易併發新生兒型呼吸窘迫症候群。會有人認為其機轉在於肺部之較成熟。本實驗以體內實驗INVIVO,體外實驗INVITRO兩種方法來評估老鼠胎兒在母體內暴露於尼古丁後,其呼吸道分支形態學之變化。體內實驗:自懷孕第九天至第十二天,分別在母鼠身上以腹腔注射的方式,注入0,2,3毫克/公斤體重/每天的尼古丁,第十三天取出胎兒肺葉,在顯微鏡下分析計算其分支與芽苞數目。結果顯示在高尼古丁組,其公支明顯減少(3.7±0.1/lobe實驗組vs.4.4±0.1/lobe對照組,F=9.4,p<0.001)。在兩組尼古丁組,芽苞數目都明顯減少(2mg/kg/day group實驗組8.7±0.5/lobe vs.3mg/kg/day group實驗組9.0±/lobe vs.對照組12.3±0.4/lobe,F=20.3,p<0.001)。體外實驗:將胎兒肺葉在第十二天分離並培養在含尼古丁(濃度0,30,60微克/毫昇)溶液中,四十八小時後在顯微鏡下觀察,三組的肺葉分支形態並無統計上之差異。本實驗不支持尼古丁可以促進肺部成熟的假說。 |
英文摘要 | Epidemiological evidence suggests that premature infants born to mothers who smoke have a lower incidence of neonatal respiratory distress syndrome. The mechanism has been proposed to be due to increased lung maturity. This in vivo study investigated the effect of maternal nicotine on lung development by evaluating the airway branching morpho genesis (ABM) in mice fetuses. Nicotine (0, 2 and 3mg/kg/day) was administered intraperitoneally to pregnant mice from gestation day 9 to day 12 (4 days). ABM was determined on day 13 by photomicrographic analysis. The results revealed a significant reduction in ABM in the higher dose nicotine group. The mean number of airway branches was 3.7±0.1/lobe for the 3mg/kg/day group, which was smaller than 4.6±0.2/lobe for the 2mg/kg/day nicotine group, and4.4±0.1/lobe for the control group (F=9.4, p<0.001). The mean number of buds was significantly smaller in both the 2mg/kg/day group and the 3 mg/kg/day group (8.7±.5/lobe, 9.0±0.4/lobe vs. 12.3±0.4/lobe in the control group, F=20.3, p<0.001). For the in vitro study, fetal lung lobes were isolated at the 12(superscript tk) gestation day. The lung explants were cultured in nicotine (0, 30, 60ng/ml) for 48 hours; there were no differences in all the groups. The results do not support the hypothesis that nicotine stimulates fetal lung ABM either in vivo or in vitro. |
本系統中英文摘要資訊取自各篇刊載內容。