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題名 | Development and in Vitro Evaluation of Chitosan-based Transdermal Nicotine Delivery System=以Chitosan為基劑之Nicotine經皮輸移系統的研發與體外評估 |
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作者 | 林恆弘; 游慧美; 蔡義弘; 許立人; | 書刊名 | 嘉南學報 |
卷期 | 26 2000.11[民89.11] |
頁次 | 頁44-53 |
分類號 | 418.6 |
關鍵詞 | 尼古丁; 幾丁質親水膠體; 經皮輸移; 熱卡氏分析; 促進劑; Nicotine; Chitosan hydrogel; Transdermal delivery; DSC analysis; Enhancer; |
語文 | 英文(English) |
中文摘要 | 尼古丁(nicotine)經皮輸藥系統已證實在最少的禁斷症狀下能有效的協助吸煙者戒除煙癮,本研究採用含chitosan之親水膠體基質型系統來製備-透明且與水可溶╱可混合之凝膠軟膏;其物理化學性質則以Cone and Plate黏度計與熱卡氏分析儀來檢測;此外,有關軟膏性質對nicotine自chitosan親水膠體釋出以及經皮吸收的影響,則是以體外實驗來探討。結果指出,含chitosan之親水膠體當加入可溶性的尼古丁時會因形成塊狀物而出現混濁的現象,但隨著乳酸的逐步添加則沉澱物再次液化又恢復成原先的澄明外觀,此製品經由熱分析證實,nicotine與軟膏各組成分之間並無化學反應發生。而藥物的釋出速率與膠體基劑的黏稠度是呈反比的關係。由體外皮膚的穿透實驗得知,僅有些微的尼古丁能穿透老鼠皮,當併合使用benzalkonium chloride作為促進劑則可明顯的促進尼古丁的經皮吸收。 |
英文摘要 | Nicotine transdermal delivery systems (nicotine-TDSs) have provided effective assistance to smokers in smoking cessation with minimal occurrence of withdrawal symptoms. A hydrocolloidal matrix system containing complexes of chitosan was investigated for preparing a transparent and water-soluble/miscible gel ointment. The physicochemical properties of ointment was determined by Cone and Plate viscometer and differential scanning calorimetry. Further, the effect of properties of ointment on the release of nicotine from chitosan hydrogel and percutaneous absorption was assessed by in vitro studies. The gel initially hardened when nicotine was used but did subsequently liquefy by adding lactic acid. The DSC measurements indicated that the components of the ointment did not chemically interact with one another. An increase in drug release rate was associated with a corresponding decrease in the viscosity of gel. In the in vitro skin permeation studies, only trace amount of nicotine had permeated through the rat skin. A much greater enhancing effect could be achieved when benzalkonium chloride was incorporated into chitosan gels. |
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