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頁籤選單縮合
題名 | Polycystic Overy Syndrome (PCOS), Insulin Resistance and Insulin-Like Growth Factors (IGFs)/IGF-Binding Proteins (IGFBPs)=多囊性卵巢症候群、胰島素抗性、與類胰島素生長因子及類胰島素生長因子結合蛋白 |
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作者姓名(中文) | 王馨世; 王子豪; | 書刊名 | 長庚醫學 |
卷期 | 26:8 2003.08[民92.08] |
頁次 | 頁540-553 |
分類號 | 417.12 |
關鍵詞 | 多囊性卵巢症候群; 胰島素過高血症; 雄性素過高血症; 抗雄性素製劑; 胰島素抗性; 類胰島素生長因子; 類胰島素生長因子結合蛋白; 促胰島素敏感化製劑; Polycystic ovary syndrome; PCOS; Hyperinsulinemia; Hyperandrogenism; Antiandrogens; Insulin resistance; Insulin-like growth factors; IGFs; IGF-binding proteins; IGFBPs; Insulin-sensitizing agents; |
語文 | 英文(English) |
中文摘要 | 多囊性卵巢症候群(PCOS)是卵巢功能最常見之良性素異常。胰島素過高血症合併胰島素抗性是誘發多囊性卵巢症候群症狀(如:無排卵性不孕、及雄性素過高血症)最主要之關鍵,改善胰島素抗性所導致之胰島素過過血症可以緩和多囊性卵巢症候群之症狀。與正常之同年齡婦女比較,多囊性卵巢症候群之病人有較高的機率罹患糖尿病、高血壓、及心臟血管疾病。雖然回服避孕藥、黃體素、抗雄或素製劑、及促排卵藥為多囊性卵巢瘧候群之標準療法,但仍須積極地鼓勵病人減肥,因減肥可以件低新陳代謝異常誘疑之後遺症。目前,促胰島素敏感化製劑的單獨使用、或合併其他標準療法,能改善多囊性卵巢症候群病人之胰島素過高血症。最重要的是,儘早診斷高危險群之病人、即刻開始治療、以及長期之追蹤,可以改善及提升病患之健康。 |
英文摘要 | Polycystic ovary syndrome (PCOS) is the most frequent androgen disorder of oveaian function. Hyperinsulinemia with insulin resistance is believed to be a key link in the enigmatic generation of the symptoms of PCOS such as anovulatory infertility and hyperandrogensim. Regression of these symptoms may be achieved by reducing the hyperinsulinemia. A growing body of evidence suggests that PCOS patients with hyperinsulinemia have a higher risk to develop diabetes mellitus, hypertension and cardiovascular disease as compared to age-matched ownmen. Althought oral contraceptives, progestins, antiandrogens, and ovulation induction agents remain standard therapies, weight loss should also be vigorously encouraged to ameliorate the metabolic consequences of PCOS. In addition, insulin-sensitizing agents are now being shown to the useful alone or combined with standard therapies to alleviate hyperinsulinemia in PCSO. Finally and most importantly, early identification of patients at risk and prompt initiation of therapies, followed by long-term surveillance and management, may promote the patient’s long-term health. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。