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頁籤選單縮合
題名 | Relationship between Umbilical Cord Blood Insulin-Like Growth Factors and Anthropometry in Term Newborns=臍帶血中類胰島素生長因子之濃度與足月新生兒體型之關係 |
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作者姓名(中文) | 洪德育; 林鏡川; 黃雅淑; 林秀娟; 周言穎; 蔡文暉; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷期 | 49:1 2008.01-02[民97.01-02] |
頁次 | 頁19-23+44 |
分類號 | 417.517 |
關鍵詞 | 出生體重; 第一型類胰島素生長因子; 第二型類胰島素生長因子; 第三型類胰島素生長因子結合蛋白; Birth weight; Insulin-like growth factor I; Insulin-like growth factor II; Insulin-like growth factor binding protein-3; |
語文 | 英文(English) |
中文摘要 | 背景:出生之體型可能與成年人之疾病有關。類胰島素生長因子是影響胎兒生長最重要之內分泌因素。研究報告顯示在快速生長時有較高之游離總第一型類胰島素生長因子比例,所以生物利用率較高。本研究的目的是探討類胰島素生長因子系統之主要成分:游離及總第一型類胰島素生長因子和其比例、第二型類胰島素生長因子及第三型類胰島素生長因子結合蛋白臍帶血中之濃度與足月新生兒體型之關係。方法:我們總共收集了95個健康足月新生兒之臍帶血,使用酵素免疫吸附法來測量荷爾蒙之濃度。結果:體重大於妊娠週數體重之新生兒比體重低於妊娠週數體重之新生兒有較高之游離及總第一型類胰島素生長因子和第二型類胰島素生長因子結合蛋白(P<0.01,0.001及0.01),並且比適當妊娠週數體重之新生兒有較高之總第一型類胰島素生長因子及第三型類胰島素生長因子結合蛋白(P<0.05及0.01)。然而游離總第一型類胰島素生長因子比例及第二型類胰島素生長因子臍帶血濃度則沒有差別。相關分析顯示,游離和總第一型類胰島素生長因子,以及第三型類胰島素生長因子結合蛋白臍帶血濃度與出生體重有正相關(r=0.34, P<0.001; r=0.41, P<0.001; r=0.25, P<0.05)。多重迴歸分析顯示,只有總第一型類胰島素生長因子臍帶血濃度是預測出生體重之獨立變項。結論:接近足月時,類胰島素生長因子中,總第一型類胰島素生長因子是決定胎兒成長之最重要因素。如果出生體型與成年人之慢性疾病有關,總第一型類胰島素生長因子在致病機轉中可能有扮演某種角色。 |
英文摘要 | Background: Birth size is associated with long-term morbidity. Insulin-like growth factor (IGF) system is the most important endocrine factor influencing fetal growth. During rapid somatic growth, free-to-total IGF-Ⅰ ratio is increased, resulting in higher IGF-Ⅰ bioavailability. The purpose of this study was to investigate the association of free-to-total IGF-Ⅰ ratios, IGF-Ⅱ, and IGF-binding protein (IGFBP)-3 umbilical cord levels with anthropometric data of term neonates. Methods: Umbilical venous plasma samples were obtained from 95 term neonates and analyzed by enzyme-linked immunosorbent assay. Results: The large-for-gestational age (LGA) neonates had higher free IGF-Ⅰ, total IGF-Ⅰ, and IGFBP-3 levels than small-for-gestational age (SGA) neonates (P<0.01, 0.001, 0.01, respectively) and higher total IGF-I and IGFBP-3 levels than appropriate-for-gestational age (AGA) neonates (P<0.05, 0.01, respectively). The free-to-total IGF-Ⅰ ratios and IGF-Ⅱ levels were not different among SGA, AGA, and LGA neonates. Free IGF-Ⅰ, total IGF-Ⅰ, and IGFBP-3 levels were positively correlated with birth weight (r=0.34, P<0.001; r=0.41, P<0.001; r=0.25, P<0.05, respectively). Multiple linear regression analyses revealed that only total IGF-Ⅰ levels was the independent predictive variable for birth weight. Conclusions: Our data suggest total IGF-Ⅰ is the most important factor in the IGF system for determining fetal growth, at least near term gestation. Free-to-total IGF-Ⅰ ratios may mostly be determined by total IGF-Ⅰ. If birth size is associated with adult chronic metabolic diseases, total IGF-Ⅰ may be involved in the pathogenesis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。