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題 名 | d,1-型環丁基丙烯氨圬鎝氧錯合物晶體分解反應之研究=Study on the Decomposition of Single Crystal of 阷Tc(V)O-d,l-CB-PAO Complex |
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作 者 | 蔡長書; | 書刊名 | 慈濟技術學院學報 |
卷 期 | 5 2003.09[民92.09] |
頁 次 | 頁77-93 |
分類號 | 418.346 |
關鍵詞 | 鎝(V)氧-環丁基丙烯氨圬錯合物; 配位子; 單晶; 水溶性; 親脂性; 阷Tc(V)O-d,l-CB-PAO complex; Ligand; Single crystal; Hydrophilic; Lipophilic; |
語 文 | 中文(Chinese) |
中文摘要 | 在較高倍率掃描式電子顯微照相觀察下,鎝氧環丁基丙烯氨圬(99Tc(V)O-d,l-CB-PAO )單晶原為細長棒狀結晶,因不穩定分解產生團縮或蛀洞,晶面出現皺折或不規則碎裂。而未長晶之前已變黑之母液乾燥物,或已破壞分解之99Tc(V)O-d,l-CB-PAO 晶體,經由 1H-NMR 核磁共振光譜測試,只發現一較強的溶劑波峰(solvent peak) 吸收,可推測錯合物可能分解產生順磁性的 TcO2 之故。13C-NMR 核磁共振光譜結果亦知其不 同 環 境 碳種類(carbon style )僅有一組,已小於未分解前99Tc(V)O-d,l-CB-PAO 理 論 上 應 有 的 十 二 組 不 同 環 境 碳種類,顯示其立體化學結構亦已改變。另由紫外光-可見光光譜之測定,99Tc(V)O-d,l-CB-PAO 單晶可能由於水解或自身氧化還原,而分解產生游離態過鎝酸根離子(free 99TcO4- )和游離態的d,l-CB-PAO配位子或某些水 溶 性 的未知新物種。此一實驗結果與文獻報導, 99mTc(V)O-d,l-HM-PAO 配 劑 後,有 體 外 不 穩 定 分 解 現 象 及 進 入 血 腦 障 壁 後 因 親 脂性 變 為 水 溶 性 物 種 而 滯 腦,有 相 同 現象與特性。因而,初步可推論99mTc(V)O-d,l-CB-PAO 與 99mTc(V)O-d,l-HM-PAO 有 類 似 的 體 內 滯 腦 機 制。 |
英文摘要 | The single crystal of 99Tc(V)O-d,l-CB-PAO was observed under scanning electron microscope(SEM) with an enlargement of ×20-200,000, and was found the well-defined bar-like crystal. Due to the in vitro instability of 99Tc(V)O-d,l-CB-PAO complex, SEM micrographs of decomposed fractions clearly revealed some distinct crystal characters: ill-defined irregular bars stunk together into amorphous looking materials. The black amorphous 99Tc(V)O-d,l-CB-PAO fractions which sampling from the dried mother liquor were measured by using 1H-NMR spectroscopy. It was found that one strong solvent absorption peak displays only. This may support that 99Tc(V)O-d,l-CB-PAO has decomposed and produced a paramagnetic TcO2 species. In addition, 13C-NMR spectroscopy of decomposed 99Tc(V)O-d,l-CB-PAO displays only one kind of carbon type, but that of undecomposed 99Tc(V)O-d,l-CB-PAO should exist 12 kinds of C type theoretically. It appears that the stereochemical structure of 99Tc(V)O-d,l-CB-PAO has clearly been changed. According to results of UV-vis spectroscopy, the single crystal of 99Tc(V)O-d,l-CB-PAO has been decomposed and it may produce free 99TcO4-, isolated d,l-CB-PAO ligand and new unknown hydrophilic species by means of hydrolysis or self-oxidation and reduction. Base on the experimental results shown above with those found in the literatures, one notices that in vitro instability of 99mTc(V)O-d,l-CB-PAO was observed similarly compared to commercial 99mTc(V)O-d,l-HM-PAO now in clinic use. Extensive studies have confirmed that the lipophilic 99mTc(V)O-d,l-HM-PAO complex is possible to be metabolized and changed into hydrophilic species when crossing the blood-brain barrier(BBB). Therefore, it seemed that in vivo brain uptake and retention mechanism of 99mTc(V)O-d,l-CB-PAO is similar with that of 99mTc(V)O-d,l-HM-PAO. |
本系統中英文摘要資訊取自各篇刊載內容。