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題 名 | Cutaneous Post-irradiation Angiosarcoma--A Case Report and a Review of the Literature=放射線治療後皮膚血管肉瘤--病例報告暨文獻回顧 |
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作 者 | 王淳樺; 陳國熏; 蔡坤寶; | 書刊名 | 中華皮膚科醫學雜誌 |
卷 期 | 21:2 2003.06[民92.06] |
頁 次 | 頁180-186 |
分類號 | 415.641 |
關鍵詞 | 放射線治療; 皮膚血管肉瘤; Angiosarcoma; Abdominal wall; Irradiation radiotherapy; |
語 文 | 英文(English) |
中文摘要 | 皮膚血管肉瘤是源自於血管內皮細胞罕見的惡性腫瘤,極少發生於腹壁,其致病因子甚為複雜,包括有因放射線治療其他惡性腫瘤所導致的皮膚血管肉瘤。目前只有數個病例報告是骨盆腔內惡性腫瘤接受放射線治療後,於腹壁上罹患皮膚血管肉瘤。吾人提出一位因子宮頸上皮鱗狀細胞癌接受體外放射線治療後八年,於腹壁上罹患皮膚血管肉瘤的病例報告。經由組織病理及組織化學免疫學(包括Vimentn,CD31和CD3的陽性反應;Cytokeratin,S-100和LCA的陰性反應)的確診。雖然該病人於確診後接受手術全切除、皮瓣移植及化學等治療,仍不幸於六個月後因敗血症死亡。我譬整理此病例並回顧自1960至2002年的相關文獻。 |
英文摘要 | Cutaneous angiosarcoma(AS) is a rare malignancy arising from vascular endothelium, and occurs extremely rarely on the abdominal wall. Several predisposing factors, including external irradi- ation for another malignancy have been suggested. Few cases of abdominal-wall AS in patients previ- ously treated with pelvic irradiation for gynecological malignancies have been reported hitherto. Herein, we describe a patient with squamous cell carcinoma of uterine cervix developed a cutaneous AS eight years after radiotherapy. The diagnosis was confirmed by histopathological and immunohis- tochemical studies, which showed positive staining for Vimentin, CD31 & CD34 while negative stain- ing for Cytokeratin, S-100 & LCA. She received aggressive multi-modality therapy including total excisin of tumor, skin flap and chemotherapy but died 6 months after the initial diagnosis of AS. The literature between 1960 and 2002 was also reviewed. |
本系統中英文摘要資訊取自各篇刊載內容。