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頁籤選單縮合
題 名 | Association of Endostatin D104N with Leukemia=Endostatin D104N和白血病之相關性 |
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作 者 | 劉大智; 彭慶添; 林勝豐; 張肇松; 陳田柏; 張建國; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 19:1 2003.01[民92.01] |
頁 次 | 頁1-5 |
分類號 | 415.635 |
關鍵詞 | 白血病; Endostatin基因; 多形性; Endostatin gene; Polymorphism; Leukemia; |
語 文 | 英文(English) |
中文摘要 | 本研究蒐集 126 位急性骨髓性白血病患者(AML),57 位慢性骨髓性白血病患者(CML),91 位急性淋巴性白血病患者(ALL)和 178 位健康對照組的骨髓或週邊血液檢體,利用 PCR-RFLP 方法分析並評估 endostatin 基因多形性變化和白血病的相關性。結果顯示 4349G(104D)對偶基因在 178 個正常台灣人的頻率為 98%(384/356)。而 4349A(104N))其頻率為 2%(8/356)、4349G/G 之同合子為 170/178(95.5%),4349G/A 雜合子為 8/178(4.5%),我們並未發現 4349A/A 之同合子。在 AML 患者、CML 患者、ALL 患者之 4349G/G 各為124/126(98.4%)、55/57(94.9%)、89/91(97.9%);4349G/A 各為 2/126(1.6%)、2/57(5.1%)、2/91(2.1%)。在患者組中亦未發現到 4349A/A。故在白血病患者的 endostatin 基因多形性和健康對照組有相近的頻率,在統計上並無差異。因此我們的結論為 endostatin 基因多形性和白血病並無相關。 |
英文摘要 | The bone marrow and/or peripheral blood from 126 patients with acute myeloid leukemia (AML), 57 with chronic myeloid leukemia (CML), 91 with acute lymphocytic leukemia (ALL), and 178 normal controls were analyzed using a polymerase chain reaction-restriction fragment length polymorphism (RFLP) assay to evaluate the association of the endostatin polymorphisms D104N (nucleotide 4349G A) with leukemia. In the 178 normal Taiwanese, the allele frequency of 4349G was 98% (348/356) and that of 4349A was 2% (8/356). The frequencies of homozygous 4349G (104D/D) and heterozygous 4349G/A (104D/N) were 95.5% (170/178) and 4.5% (8/178), respectively. However, no individuals were homozygous 4349A (104N/N). Among the leukemia patients, 124/126 with AML (98.4%), 55/57 with CML (94.9%), and 89/91 with ALL (97.9%) were homozygous 4349G. In addition, 2/126 with AML (1.6%), 2/57 with CML (5.1%), and 2/91 with ALL (2.1%) were heterozygous 4349G/A. No patients were homozygous 4349A. Similar frequencies of endostatin polymorphisms were observed in leukemic patients and normal controls. This suggests that the endostatin polymorphism is not associated with the risk of leukemia. |
本系統中英文摘要資訊取自各篇刊載內容。