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| 題 名 | A Histomorphometric Study of Effects and Mechanism of Localized Cobalt-60 Irradiation on Bone=局部鈷六十放射線照射對骨組織影響的研究 |
|---|---|
| 作 者 | 史中; | 書刊名 | 中華民國口腔顎面外科學會雜誌 |
| 卷 期 | 14:1 2003.03[民92.03] |
| 頁 次 | 頁11-17 |
| 分類號 | 416.95 |
| 關鍵詞 | 骨; 放射性鈷六十照射; 造骨細胞; 破骨細胞; Bone; Cobalt-60 irradiation; Osteoblast; Osteoclast; |
| 語 文 | 英文(English) |
| 中文摘要 | 本研究中使用64隻3月大ICR小白鼠,按隨機抽樣法分成對照組和放射線照射組。在鈷六十放射線 (12格雷) 局部照射於大白鼠右側股骨和腔骨。動物分別於照射後1、7、14或28天犧牲。動物犧牲後,利用靜態與動態骨組織形態學計量法等進行放射線局部照射後,骨生成和骨吸收各項參數的計量與分析以及放射線照射對骨組織影響機轉的探討。鈷六十放射線照射後七天時發現破骨細胞平均含核數和骨吸收表面顯著地增加,而單位面積造骨細胞數目,硬組織百分比,骨百分比,骨小樑厚度,骨小樑礦物質沈積達率及骨小樑骨生成速率則明顯地降低,在照射後28天則發現土述參數有逐漸回復正常之趨勢。 局部性鈷六十投射線照射會導致:1) 破骨細胞平均含核數和骨吸收表面明顯遞增加和2) 造骨原始細胞增生、造骨細胞的活性及礦物化作用明顯地減少。因此,局部性社射線鈷六十照射會導致骨質流失之發生。 |
| 英文摘要 | The purpose of this study were to investigate the effects and mechanism of localized cobalt-60 irradiation (IR)on bone using static and dynamic bone histomorphometric analysis and the mechanisms of irradiation-induced bone loss. Sixty four 3- month old male ICR mice were randomly assigned into control and irradiated (IR) groups. Eight rats of each group were sacrified at 1, 7, 14 or 28 days after 12 Gy of localized cobalt-60 irradiation on right femur and tibia. The parameters of bone formation and bone resorption, and the mechanism of IR on bone tissue were evaluated using static and dynamic bone histomorphometry. Seven days after localized cobalt-60 irradiation, there were significant increases in osteoclastic number and activity, and decreases in OB/mm2 . A significant decrease in OC/mm2 occurred 14 days after irradiation. No significant difference were found in percent hard tissue, percent bone, trabecular thickness, mineral apposition rate and bone formation rate between the cobalt-60 irradiated and control group 1 day after irradiation. However, they became significantly less on day 7 and began to resume on the day 28 after irradiation. Therefore, cobalt-60 irradiation could significantly increase osteoclastic bone resorption. In addition, it significantly decrease osteoblast differentiation and induce dramatic bone loss. In conclusion, cobalt-60 could result in osteopenia. |
本系統中英文摘要資訊取自各篇刊載內容。