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相關文獻
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頁籤選單縮合
題名 | Review of the Hepatitis C Virus C Gene=丙型肝炎病毒核基因研究的回顧 |
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作者姓名(中文) | 羅時燕; | 書刊名 | 慈濟醫學 |
卷期 | 14:5 2002.10[民91.10] |
頁次 | 頁275-280 |
分類號 | 415.5332 |
關鍵詞 | 丙型肝炎病毒; 核蛋白; 脂肪變性; 細胞凋亡; 腫瘤形式; Hepatitis C virus; Core protein; Steatosis; Apoptosis; Oncogenesis; |
語文 | 英文(English) |
中文摘要 | 丙型肝炎病毒的感染會引起慢性肝炎、肝硬化、甚至肝癌。關於丙型肝炎病毒的致病機轉,目前不甚明瞭。但丙型肝炎病毒的致病機轉至少有些直接是病毒的蛋白引起的,像核蛋白。由於是病毒的核心結構蛋白,丙型肝炎病毒核蛋白有它本質上的結構特性。它可以專一的和丙型肝炎病毒基因體核糖核酸相結合,和膜蛋白作用,並形成類病毒顆粒。除了它的結構特性外,丙型肝炎病毒核蛋白也有調節性的功能。它可以調控多種細胞及病毒基因的表達;更且,它會引起脂肪變性,調節細胞凋亡,增加細胞的致癌性。除了核蛋白外,在丙型肝炎病毒核基因內,尚有一蛋白產生。此蛋白的產生,是核糖體轉譯時,改變其轉譯系列所致。目前不知這新蛋白的功能。這新蛋白的存在是十分令人感興趣的,因為黃熱病毒科的其它成員均無類似蛋白的產生。 |
英文摘要 | Infection with hepatitis C virus (HCV) can cause chronic hepatitis, cirrhosis, and even hepatocellular carcinoma (HCC). Molecular mechanisms of HCV pathogenesis are largely unknown. Some aspects of HCV pathogenesis may be directly attributed to individual HCV proteins, such as the core protein. As a virnal capsid protein, HCV core protein has authentic structural properties. It binds HCV RNA specifically, interacts with envelope proteins, and forms virus-like particles. In addition to its structural properties, HCV core protein has also been demonstrated to possess various regulatory functions. It regulates the expression of several cellular and viral genes. Moreover, it has been shown to induce steatosis, modulate apoptosis, and increase cellular oncogenic potential. There is another protein with a different open reading frame from core protein within the HCV C gene. This protein is produced through ribosomal frameshift (F protein). The function of the F protein is unknown. The detection of the F protein is quite interesting since no other members of the Flaviviridae family have similar products. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。