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題 名 | Photosensitizing Capabilities of Photofrin[feb9] in Vascular Endothelial Cells=Photofrin[feb9]光顯劑於血管顯微內皮細胞及惡性病變光顯能力之評估 |
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作 者 | 張承仁; 馬淑芳; 魏福全; | 書刊名 | 臺灣外科醫學會雜誌 |
卷 期 | 34:6 民90.11-12 |
頁 次 | 頁287-293 |
分類號 | 416.36 |
關鍵詞 | 光顯劑; 血管顯微內皮細胞; 惡性病變; Photofrin[feb9]; Microvascular endothelial cell; Chicken combs; |
語 文 | 英文(English) |
英文摘要 | The object of the present study was to evaluate the feasibility of photodynamic therapy (PDT) using Photofrin R(porfimer sodium),an United States Food and Drug Administration approved photosensitizer.The in vitro absorption and photosensitizing activities of PhotofrinR were evaluated with cultured human microvascular endothelial cells and in vivo activities were evaluated with ductal carcinoma cell stimulated mammary tumor.The viability of microvascular endothelial cells was assessed using rhodamine-phallodin coupled α -tubulin antibody speific for cytoplasmic microtubule and visualized by immunofluorescence microscopy.At the optimal wavelength of 630 nm,the percentage of microvascular endothelial cells killed by variable concentrations of PhotofrinR was measured by either live/dead or lactate dehydrogenase-released assays and the in vivo biological activity was assessed by determining the amount of necrosis produced in stimulated mammary tumor. A combination of 3.5μg/mL PhotofrinR and laser light at 630 nm with a power density of lOO mW/cm2 resulted in a 5O% cell kill﹒The lactate dehydrogenase released from microvascular endothelial cells after PDT showed a 50% optical density obtained from each concentration of photosensitizerof 5O% cell killing after laser illumination.Stained histology specimens of stimulated mammary tumor demonstrated significant vascuIar destruction l hour after PDT.In conclusion,PhotofrinR has the capabilities to destroy microvascular endothelial cells in vitro and vasculature in vivo.However, the degree of absorption and tissued destruction in vasculature in vivo and different anatomical structures should be considered and will be included in our subsequent studies. |
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