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題名 | 缺血性大腸炎與市售成藥--感冒糖漿的關係=Ischemic Colitis Associated with Business Patent Medicine--Common Cold Syrup |
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作者 | 鄭幼文; 鄭勝雄; 葉錦龍; 柯朝元; Cheng, Yoiu-wen; Cheng, Sheng-hsiung; Yeh, Chin-long; Ko, Chou-yuan; |
期刊 | Journal of Medical Sciences |
出版日期 | 20021100 |
卷期 | 22:專刊 民91.11 |
頁次 | 頁45-49 |
分類號 | 415.556 |
語文 | chi |
關鍵詞 | 缺血性大腸炎; 鼻部去充血劑; 偽麻黃素; Ischemic colitis; Nasal decongestant; Pseudoephedrine; |
中文摘要 | 缺血性大腸炎在老年人大腸疾病中是一常見的疾病,也是腸道缺血病變中最常發生的疾病。引發缺血性大腸炎可能是全身處在低血壓併血液灌流不足的狀態下,或是本身腸繫膜血管生理或功能的改變。造成上述常見的原因包括:心衰竭、心律不整、血管的粥狀硬化或栓塞、手術及藥物等。大部份缺血性大腸炎的患者可能找不到特別的誘發因素,但或許有些藥物的因素是我們沒意到的。許多的藥物可引起缺血性大腸炎在過去的文獻中已早有報告,在國外最近的文獻中曾有三篇提及含偽麻黃素(Pseudoephedrine)的鼻部去充血劑,可以引起缺血性大腸炎。同樣地,本院最近二年內發現了三位因感冒服用感冒糖漿後產生腹痛,血便的患者,經過病史詢問、糞便檢驗、大腸鋇劑攝影、大腸鏡併切片檢查,確定為缺血性大腸炎,經臨床治療恢復良好,追蹤12至18個月,無比人再復發。 |
英文摘要 | Ischemic colitis is a common disorder of the large intestine in the elderly and is the most common form of ischemic disease in the gastrointestinal tract. Ischemic colitis is often seen in patients subject to systemic hypotension with low flow state or function and physiological changes of mesenteric perfusion. It is caused by cardiac failure, arrhythmia, atherosclerotic disease, vessel embolus, surgical procedures and medications. Most patients have no identifiable cause of their colonic ischemic episodes, but we probably underestimated some pharmacological effects. Recent literatures showed that pseudoephedrine, a nasal decongestant, could induce ischemic colitis. We had 3 patients presenting with abdominal pain and passage of bloody stool following ingestion of common cold syrup in recent two years. Ischemic colitis was confirmed by barium enema study and colonosocopic biopsy. All patients recovered biopsy. All patients recovered after medical treatment without recurrent attack within 12 to 18 months. |
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