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題名 | 併發於深部靜脈栓塞的脂肪皮膚硬化症--以stanozolol治療之經驗=Lipodermatosclerosis Complicating Deep Vein Thrombosis--A Case Treated with Stanozolol |
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作者姓名(中文) | 童麗娜; 陳信吉; 蘇信義; | 書刊名 | 中華皮膚科醫學雜誌 |
卷期 | 20:3 2002.09[民91.09] |
頁次 | 頁234-240 |
分類號 | 415.763 |
關鍵詞 | 深部靜脈栓塞; 脂肪皮膚硬化症; Lipodermatosclerosis; Stanozolol; |
語文 | 中文(Chinese) |
中文摘要 | 一位21歲男性,在其左小腿內側及左腳踝各有一塊如木板孺堅硬的棕黑色硬化斑,已有一年以上的時間,且腳踝的病灶漸漸發展出一個不易癒合的潰瘍。此病患約三年前曾有左大腿深部靜脈栓塞的病史。根據臨床表現、組織病理學及免疫螢光檢查,我們診斷此病患為一脂肪皮膚硬化症的病例。臨床症狀在給與stanozolol治療6週後有改善,包括潰瘍縮小,脂肪皮膚硬化症病灶變軟且面積變小,且血中之fibrinogen值有明顯下降。但由於病患之肝功能持續惡化,因而停止投與stanozolol。停藥3週後,病患的肝功能恢復正常,但血中之fibrinogen值又再度上升。 |
英文摘要 | A 21-year-old male had noted two slowly enlarging, hyperpigmented sclerotic patches on his left leg and ankle respectively for more than one year; in the meantime, the lesion on the ankle progressed into a poor-healing deep ulcer gradually, He had a history of deep vein thrombosis of left thigh occurring about three years ago. The diagnosis of ipodermatosclerosis was established on the basis of clinical manifestation, histopathology and immunofluorescence examination. After six weeks of stanozolol therapy, the ulcer shrinked obviously, and the sclerotic patches became less indurated and decreased in size. In addition, the plasma fibrinogen level was also decreased significantly. However, because of the sustainedly elevated serum transaminase level. We discontinued the oral stanozolol. Three weeks later, the liver function recovered, but the plasma fibrinogen level elevated again. |
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