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頁籤選單縮合
題名 | The Preparation of Enoxacin-loaded Liposomes and Its in Vitro Evaluation in Pig's Eye=負載Enoxacin微脂粒之製備及其在體外豬眼睛之評估 |
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作者 | 林恆弘; 游慧美; 蔡義弘; 許立人; Lin, Hung-hong; Yu, Hui-mei; Tsai, Yi-hung; Hsu, Li-ren; |
期刊 | 嘉南學報 |
出版日期 | 20011100 |
卷期 | 27 2001.11[民90.11] |
頁次 | 頁89-96 |
分類號 | 418.2323 |
語文 | eng |
關鍵詞 | 微脂粒; 經眼角膜; 豬眼睛; Liposomes; Enoxacin; Transcorneal; Pig's eye; |
中文摘要 | 不同的磷脂質在本文中被選用來製備微脂粒並評估其眼角膜的穿透特性。本研究 則是以 Enoxacin 為微脂粒處方的模式藥物,經由合併乙醇注入技術與凍晶乾燥過程,使微 脂粒的包埋效率相較於傳統的薄膜方法提升約九倍之多;在體外的角膜穿透試驗中顯示,微 脂粒負載型藥物穿透角膜的速率比游離態藥物來得低,然而,微脂粒負載 Enoxacin 主要是 蓄積在眼角膜內,脂質種類對藥物角膜內滯留的影響依序是 DSPC > DPPC > DMPC。 最後, 熱卡式分析被用以檢測微脂粒與眼角膜間所可能發生的交互作用,結果指出,微脂粒可藉由 改變細胞架構來傳輸進入眼角膜,亦有可能是經由胞飲作用而攝入。 |
英文摘要 | Varing phospholipids were used to prepare liposomes which were used to perform the evaluation of transcorneal characteristics. Enoxacin was selected as a model drug incorporated in various liposomal formulations as a therapeutic dosage form. Using a combination of the ethanol injection technique and freeze-drying process, the encapsulation efficiency became 9-fold greater than that obtained by using a conventional film method. In the in vitro corneal perfusion studies, enoxacin loaded-liposome was transfered through cornea at a slower rate than free drug. However, enoxacin loaded-liposomes were accumulated primarily in the cornea. The increase in the drug corneal retention for the lipids conformed to the following order: DSPC > DPPC > DMPC. Finally, the DSC analysis was utilized to determine the interaction occuring between liposomes and cornea. The liposomes must be transferred into cornea to alter the constitute of cells and can be probably taken up by the cornea via endocytosis. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。