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頁籤選單縮合
題 名 | Autologous Peripheral Blood Stem Cells Harvesting in Kaohsiung Medical University Hospital=自體週邊血液幹細胞收集之高醫經驗 |
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作 者 | 張肇松; 劉大智; 葉其鎔; 林勝豐; 陳田柏; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 17:12 2001.12[民90.12] |
頁 次 | 頁594-601 |
分類號 | 414.7 |
關鍵詞 | 自體週邊血液幹細胞; 造血幹細胞; Peripheral blood stem cells harvesting; CD34(+) cells; Cobe spectra; Haemonetic MCS3P; |
語 文 | 英文(English) |
中文摘要 | 造血幹細胞 (CD34陽性細胞) 的數目是自體週邊血液幹細胞移植成功 最重要的因素之一,也是週邊血液幹細胞收集時重要的指標。本研究針對40位 病例與112次 (88次使用Cobe收集系統、24次 MCS3P系統) 自體週邊血液幹 細胞收集術作一分析比較,並嘗試找出自體週邊血液幹細胞收集之可能影響因 素。結果發現兩套收集系統對於收集CD34(+) 造血幹細胞的效率並無顯著差 異,但Cobe系統比MCS3P系統收集較多的週邊白血球且較少紅血球污染。比 較不同天CD34(+) 細胞的收集,我們發現第一天的收集明顯高於第二天與第三 天,CD34(+)細胞之濃度有逐漸減少趨勢 ( p = 0.026 )。收集液中CD34(+) 細胞 濃度與細胞培養CFU-GM (colony forming units-granulocyte macrophage)、BFU-E (burst forming unit- erythrocyte) 間有相當好的正相關性 ( r=0.909, p<0.0001; r=0.788, p<0.0001),而與病患之年紀則成負相關。CD34(+) 細胞之收集亦與疾病 種類有關,本研究中亦發現在急性白血病病人中,其CD34(+) 細胞收集濃度顯 著高於其他固態性腫瘤。至於週邊血液幹細胞收集術相關之副作用在Cobe系統 比MCS3P系統有較高之趨勢。結論: Cobe系統與MCS3P系統對於收集CD34(+) 造血幹細胞的效率無顯著差異,而病人的年紀與疾病種類是自體週邊血液幹細胞 收集之重要影響因素。 |
英文摘要 | We report our clinical experience in autologous peripheral blood stem cells harvesting. A total of 40 patients with 112 apheresis procedures were analyzed, 88 with Cobe system and 24 with MCS3P system. Our results revealed that there was no significant difference in efficiency of CD34(+) cell harvesting between both apheresis systems, but the Cobe system had more nucleated cells collected and less red cell contaminated in the final PBSCs collections. The percentage of CD34(+) cells collected decreased significantly following the first day harvesting (p = 0.026). There was a good correlation between the percentage of CD34(+) cells in PBSCs and colony forming units ?granulocyte macrophage (CFU-GM) or burst forming unit- erythrocyte (BFU-E)(r=0.909, p<0.0001; r=0.788, p<0.0001, respectively). However, it was negatively correlated with the patient(9273) age. The CD34(+) cells collected in patients with acute leukemias were also higher than those patients with other solid tumors. Ten cases (13 %) with 15 apheresis procedures experienced side effects like numbness, nausea, fever, or headache etc. The Cobe system seemed to have higher frequency of side effects than that of MCS3P system (16 % vs 4 %). From our results, we concluded that both COBE and MCS3P system have similar efficiency and all patients could tolerate the apheresis procedures in peripheral blood stem cells harvesting. The CD34(+) cell can be used as a good parameter to estimate the amount of stem cells collected. The patient(9273) age and disease pattern were significant factors influencing the CD34(+) stem cells collection in autologous peripheral blood stem cells harvesting. |
本系統中英文摘要資訊取自各篇刊載內容。