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題 名 | Positive Association of Ankylosing Spondylitis with Homozygous HLA-B2704, but Protection with B2705 in Taiwan Chinese=臺灣人僵直性脊椎炎的發病與HLA-B2704同合子有關 |
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作 者 | 施浤彰; 劉素卿; 張志鵬; 陳昇明; 邱心怡; 劉華昌; 張建國; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 17:10 2001.10[民90.10] |
頁 次 | 頁509-516 |
分類號 | 415.695 |
關鍵詞 | 臺灣; 僵直性脊椎炎; HLA-B2704同合子; HLA-B27; Subtypes; Ankylosing spondylitis; Taiwan; |
語 文 | 英文(English) |
中文摘要 | 僵直性脊椎炎是常見的慢性病之一, 95%左右的病人為HLA-B27陽 性。我們利用PCR-RFLP的方法分析HLA-B27的亞型與僵直性脊椎炎的關係。 在738位超過65歲的正常人中, 有42位 (5.7%) 為HLA-B27陽性, 其中6位 (14.3%) 為B2704的同合子, 18位 (42.9%) 為B2704的異配子, 2位 (4.8%) 同時 有B2704及B2705, 1位 (2.3%) 同時有B2704及B2706, 2位 (4.8%) 為B2705 的同合子, 11位 (26.1%) 為B2705的異配子, 及2位 (4.8%) 為B2706的異配 子。而在62位僵直性脊椎炎的病人中, 37位 (59.6%) 為B2704的同配子, 而25 位 (40.3%) 則為B2704的異配子。由此可知, HLA-B27的帶因率在台灣地區約 為5.7%左右, 而同合子的B2704與僵直性脊椎炎的發病有關, 但B2705可能具 有保護作用。 |
英文摘要 | The study was undertaken to determine the effects of HLA-B27 subtypes on susceptibility to ankylosing spondylitis (AS) in Taiwan Chinese, a polymerase chain reaction-restrictive fragment length polymorphism (PCR-RFLP) method was developed for subtyping of HLA-B27. In this series, there are 62 patients with AS who were tested HLA-B27 positive serologically and 738 normal persons over the age of 65. Among the 738 normal controls, 42 (5.7%) were HLA-B27 positive. There were six (14.3%) homozygous for B2704, 18 (42.9%) heterozygous for B2704, 2 (4.8%) double heterozygous for B2704 and B2705, one (2.3%) double heterozygous for B2704 and B2706, 2 (4.8%) homozygous for B2705, 11 (26.1%) heterozygous for B2705, and 2 (4.8%) heterozygous for B2706. In our patients with AS, 37 (59.7%) were homozygous for B2704 and 25 (40.3%) were heterozygous for B2704. The HLA-B27 carrier rate in Taiwan healthy old persons is estimated at 5.7%. Susceptibility to AS is determined by homozygosity for B2704. However, B2705 may be an indicator of protection against AS in Taiwan Chinese. |
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