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題 名 | Biochemical Role of Nucleophosmin/B23 in Cellular Susceptibility to Induction of Differentiation and Apotosis=核仁磷酸蛋白B23在細胞分化及程式死亡之生化角色 |
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作 者 | 翁一鳴; | 書刊名 | 中華民國癌症醫學會雜誌 |
卷 期 | 15:1-4 民88.03-12 |
頁 次 | 頁1-8 |
分類號 | 361.8 |
關鍵詞 | 核仁磷酸蛋白B23; 細胞分化; 程式死亡; 生化; |
語 文 | 英文(English) |
中文摘要 | 人類原骨髓癌細胞株HL-60細胞,以維生素A酸處理,會進行顆粒性白血球分化。在維生素A酸所誘導的分化過程中或在BuONa所誘導的程式死亡,我們偵測到核仁磷酸蛋白╱B23的mRNA量及蛋白質皆會減少。由實驗中發現,RA或BuONa所誘發的B23 mRNA的穩定性所造成。而在缺乏血清培養的HL-60細胞,會造成細胞生長的停頓,此時B23 mRNA量不會受到影響,因此,B23 mRNA的減少與RA誘導細胞進行分化過程或BuONa誘導程式死亡較相關,而不是由於RA或BuONa所產生的生長停頓所造成。利用B23 antisense oligomer抑制細胞內新合成B23蛋白質的產生時,會明顯促進RA透導HL-60細胞分化及BuONa誘導程式死亡。由以上的實驗結果得知核仁磷酸蛋白╱B23蛋白質於RA所誘導的細胞分化及BuONa所誘導程式死亡過程中,扮演了重要角色。 |
英文摘要 | Human leukemia HL-60 cells were induced to undergo granulocytic differentiation or apoptosis by treatment with retinoic acid (RA) or sodium butyrate (BuONa) respectively. The steady-state level of nucleophosmin/B23 mRNA decreased during the induction of differentiation and apoptosis. There was also decrease in the level of total cellular nucleophosmin/B23 protein during the induced differentiation and apoptosis. Stabilization and nuclear run-on assays indicate that the decrease in nucleophosmin/B23 mRNA during the induction of differentiation and apoptosis was transcriptionally regulated. Unlike c myc mRNA, there was virtually no dedline of nucleophosmin/B23 mRNA during the growth arrest by serum-starvation. The decrease in mucleophosmin/B23 mRNA expression in HL-60 cells subsequent to RA or BuONa treatment can thus be attributed to cellular differentiation or apoptosis rather than the growth arrest induced by RA or BuONa. Nucleophosmin/B23 antisense oligomer treatment significantly potentiated induced cellular differentiation and apoptosis. Results of this study suggest that nucleophosmin/B23 is one of the key elements in the regulation of nucleolar function for cellular differentiation and apoptosis. |
本系統中英文摘要資訊取自各篇刊載內容。