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題 名 | Transcriptional mRNA of Bone Morphogenetic Proteins 2,3,4, and 5 in Trigeminal Nerve, Benign and Malignant Peripheral Nerve Sheath Tumors=三叉神經及良性與惡性週邊神經鞘腫瘤中二、三、四、五骨促成發育蛋白的mRNA之轉錄表現 |
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作 者 | 湯兆舜; 金岩; 程廣義; 余廣亮; 諏訪文彥; 中□勇志; 牧草一人; 方一如; | 書刊名 | The Kaohsiung Journal of Medical Sciences |
卷 期 | 17:1 2001.01[民90.01] |
頁 次 | 頁16-24 |
分類號 | 415.83 |
關鍵詞 | 週邊神經; 正位雜種化; 三叉神經; 神經鞘腫瘤; 骨促成發育蛋白; Bone morphogenetic proteins; Nerve sheath tumor; Schwann cell; In situ hybridization; |
語 文 | 英文(English) |
中文摘要 | 骨促成發育蛋白(bone morphogenetic proteins)在細胞成長及分化中扮演重要的角色。BMPs一組擴展快速的蛋白群,與變換生長因子(TGFβ)超科有密切關係,近期也被證實在神經生成過程中擁有調整及營養的角色。本研究的目的是了解BMPs 與周邊神經及神經鞘腫瘤之間的相互關係。使用正位雜種化技術,針對12例良性神經鞘腫瘤、4例惡性神經鞘腫瘤及3例三叉神經痛來探察BMPs的mRNA 轉錄情況。結果顯示三叉神經痛病例經週邊神經切除術中所穫得的許旺式細胞髓鞘內BMPs含明確的mRNA表現。然而,三叉神經的神經纖維中只有BMP-2的染色顯現。所有的腫瘤其神經鞘都呈現一致但變量的BMP-2, 3, 4, 5表現。除了BMP-4的mRNA表現外,BMP-2, 3, 5 的mRNA表現在惡性神經鞘瘤比良性的相對為低。 從以上的發現總結出,週邊神經應存在特有的BMP群,這些蛋白群可能參與週邊神經系統的健康維護、增生、再生及腫瘤變性等過程;而BMP-2, 3, 4, 5在週邊神經系統的作用及腫瘤變性的影響可能是廣泛性、多樣性及頡抗性的。 |
英文摘要 | Bone morphogenetic proteins (BMPs) have been shown to play an important role in cell growth and differentiation. BMPs, a rapidly expanding family closely related to transforming growth factor-?(TGF-? superfamily, have been proven recently to possess a regulatory role and neurotrophic capacity in neurogenesis. The aim of the present study is to reveal the relationship among BMPs, peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP 2, 3, 4 and 5 in 12 cases of schwannoma, four cases of malignant schwannoma and three cases of trigeminal neuralgia were detected using an in situ hybridization technique. Our results demonstrated that the myelin sheaths of schwann cell from the peripheral neuroectomy of trigeminal neuralgia were positively expressing mRNA of BMP-2, 3, 4 and 5. However, the nerve fibers of trigeminal nerve showed only BMP-2 positive staining. All of the neoplastic lesions of nerve sheath showed a consistent but variant expression of BMP-2, 3, 4, and 5. Except for the BMP-4 mRNA, the expression signals of BMP-2, 3 and 5 mRNA in malignant schwannoma were relatively lower than in benign lesions. On the basis of the findings, we concluded that selected members of BMPs existed in the peripheral nerves and might contribute to the health maintenance, proliferation, regeneration and neoplastic transformation of the peripheral nerve system. Moreover, the effects of BMP-2, 3, 4 and 5 on peripheral nerve system and its neoplastic transformation might be widespread, diverse and antagonistic. |
本系統中英文摘要資訊取自各篇刊載內容。