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題名 | Final Height of Children with Type 1 Diabetes: The Effects of Age at Diagnosis, Metabolic Control, and Parental Height=第一型糖尿病兒童之最終身高:診斷時年齡、代謝控制和父母身高的影響 |
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作者 | 黃琪鈺; 李燕晉; 黃富源; 許瓊心; 高信安; | 書刊名 | 臺灣兒科醫學會雜誌 |
卷期 | 42:1 民90.01-02 |
頁次 | 頁33-38 |
分類號 | 417.5937 |
關鍵詞 | 第一型糖尿病; 兒童; 最終身高; 年齡; 代謝控制; 父母身高; Type 1 diabetes; Final height; Metabolic control; |
語文 | 英文(English) |
中文摘要 | 正常的生長是治療第一型糖尿病兒童的主要目標之一。我們前瞻性地監測了44位第一型糖尿病兒童(13位男孩)自診斷時至達成年身高的線性生長和代謝控制,並分析其身高與診斷時年齡、代謝控制和父母身高的關係。在診斷之時,青春期的女孩比同齡女孩高(身高以standard deviation score表示:0.60±0.94,p=0.022),而男孩(-0.03±0.67)和未進入青春期的女孩(0.24±0.86)則與同齡兒童一樣高。經過數年的追蹤,他們的最終身高比診斷時的身高差(p=0.009),但仍達到國人平均身高(男孩-0.13±0.66,女孩-0.05±0.86),且與其診斷時的身高及父母身高有線性相關。這44位兒童的平均糖化血紅素值是10.33±1.74%,男生的代謝控制比女生好(mean HbAlc 9.45±1.28 v.s. 10.71±1.78%,p=0.013)。最終身高和最終身高與診斷時身高的差距,和診斷時的年齡沒有線性相關,和平均糖化血紅素值也沒有線性相關。 |
英文摘要 | Normal growth is one of the major goals in the treatment of children with type I diabetes. We prospectively monitored the linear growth and metabolic control of 44 children (13 boys) with type I diabetes from the time of diagnosis to the attainment of adult height and analyzed the relationship between the height and the age at diagnosis, metabolic control, and genetic target height. At diagnosis, girls at puberty were taller (height in standard deviation score: 0.60±0.94, p=0.022), while boys (-0.03±0.67) and prepubertal girls (0.24±0.86) were similar to the age-controlled children. During the following years, they lost height compared to their height at diagnosis (p=0.009), but they still attained an average final height (-0.13±0.66 in boys, -0.05±0.86 in girls) correlated with their height at diagnosis (r=0.37, p=0.014), as well as their genetic target height (r=0.78, p<0.005). The final height as well as the reduction in height was not linearly correlated with the age at diagnosis. The mean HbAlc level of the 44 children was 10.33±1.74%, boys had better control compared with girls (mean HbAlc 9.45±1.28 v.s. 10.71±1.78%, p=0.013). The final height or the reduction in height was not linearly correlated with the mean HbAlc level. |
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