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題 名 | Influence of Increased Dissolved Oxygen Tensions by Agitation on Secondary Metabolite Production by a Mutant of Aspergillus terreus in a 5L Fermentor=攪拌提升溶氧張力對Aspergillus terreus變異株於5升醱酵槽中生產其二次代謝物的影響 |
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作 者 | 賴龍山; 古建銘; 蔡幸宜; | 書刊名 | Journal of the Chinese Institute of Chemical Engineers |
卷 期 | 32:2 2001.03[民90.03] |
頁 次 | 頁135-142 |
分類號 | 460.023 |
關鍵詞 | 攪拌; 二次代謝物; Aspergillus terreus; Lovastatin; Dissolved oxygen tensions; Submerged fungal fermentations; Secondary metabolites of fungi; |
語 文 | 英文(English) |
中文摘要 | 本研究探討在5升醱酵槽中,主要以攪拌方式提升溶氧張力對A. terreus ATCC 20542高產力變異株醱酵生產其二次代謝物LOVASTATIN的影響。藉由搖瓶實驗中所測得之醱酵參數pH和PCV的變化趨勢,吾人決定16小時之移瓶時機,此時可將生長活性最高之菌絲體由種槽轉移至生產槽。再根據搖瓶實驗結果,在5升之醱酵槽操作中(設定溫度28℃、槽壓0.5kgw、通氣1.0vvm),探討提升溶氧飽和度對產物產出之影響。吾人發現此菌株二認代謝之溶氧需求是有時間性的;在醱酵24-48小時期滿日若主要靠攪拌速度來維持溶氧張力使之高於臨界值的20%,相對於125 ml搖瓶中菌株產出lovastatin的過程可提前一天左右。吾人認為主要歸因於醱酵液中有利二次代謝之菌絲顆粒的增長而非黏稠之菌絲體生長。 |
英文摘要 | We investigated the effects of dissolved oxygen (DO), influenced by agitation, on the production of lovastatin by 5L fermentations of an isolated high-producing mutant of Aspergillus terreus ATCC 20542. Using measurements of pH and packed cell volume in shaking-flask experiments, a 16hr of the cross-over timing was determined to transfer the most actively growing mycelia in seed over production. Based on results of shaking-flask experiments, we then conducted pilot-scale fermentations in a 5L fermentor at 28℃ under 0.5kgw head pressure and 1.0vvm aeration to investigate the effects of programmed DOs on lovastatin production. DO supplies were found to be important to the cells in cultures. The DO levels were critically time-dependent for lovastatin production. While increasing DO levels above 20% of saturation in 24-48hrs, this fermentor operation was found to enhance a 1-day earlier production of lovastatin, in comparison with shaking-flask data. The enhancement was mainly attributed to the formation of compact pellets rather than viscous and filamentous mycelium growth. |
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