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頁籤選單縮合
題名 | Correlation of Intraplatelet Calcium Concentration and pH with Kt/V and Blood Pressure in Maintenance Hemodialysis Patients=長期透析患者血小板內鈣離子濃度和pH與Kt/V和血壓的相關性 |
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作者 | 陳培源; 蔡銘川; 簡孝文; 陳錫賢; | 書刊名 | 臺灣腎臟醫學會雜誌 |
卷期 | 14:3 2000.09[民89.09] |
頁次 | 頁97-101+132 |
分類號 | 415.816 |
關鍵詞 | 透析劑量; 血小板鈣離子濃度; 血壓; 細胞pH; Platelet calcium; Cell pH; Blood pressure; Dialysis dose; |
語文 | 英文(English) |
中文摘要 | 本研究的目的是控討長期血液透析患者血小板內鈣離子濃度(〔Ca²+〕)及細胞pH(pHi)和Kt/V及平均血壓(MAP)的相關性。分別使用二種螢光劑,Fura-2及BCECF測量血小板〔Ca²+〕i和pHi,血液透析前尿毒患者血小板〔Ca²+〕i及pHi比對照組分別呈有意差的升高及降低(106 ± 26 vs 87 ± 18 nmo/L; 7.11 ± 0.06 vs7.15 ± 0.04, p<0.01)。血小板〔Ca²+〕i與MAP呈有意義的正相關(r=0.587, p<0.02)與Kt/V呈有意義的負相關(r=-0.77,p<0.001),但與pHi並無相關性。pHi與MAP及Kt/V均無相關性。然而Kt/V與MAP呈有意義的負相關(r=-0.574,p<0.009)。Kt≥1.4的患者其MAP(91 ± 9 vs 110 ± 12 mmHg,p<0.01)及血小板〔Ca²+〕i(88 ± 19 vs 126 ± 17 nmol/L,p<0.01)均比Kt/V<1.4的患者呈有意義的降低。結論:長期血液透析的患者透析前血小板〔Ca²+〕i、MAP和Kt/V間有密切的相關性,透析劑量較高的患者其血小板〔Ca²+〕i及MAP較低。 |
英文摘要 | The aim of this study was to investigate the correlation between Kt/v, platelet intracellular calcium concentration (〔Ca²+〕i), intracellular pH (pHi) and blood pressure in maintenance hemodialysis (HD) patients. Platelet 〔Ca²+〕iand pHi were measured by fluorescent method using Fura-2 and BCECF, respectively. Platelet 〔Ca²+〕i was significantly higher (106 ± 26 vs 87 ± 18 nmole/L, p<0.01) and pHi was significantly lower (7.11 ± 0.06 vs 7.15 ± 0.04, p<0.01) in uremic patients than in the control subjects. Platelet 〔Ca²+〕i showed significant positive correlation (r=0.587, p<0.02) to mean arterial pressure (MAP) and strong negative correlation (r=-0.77,p<0.001) to Kt/V, but no significant correlation to pHi. Platelet pHi did not have any significant correlation to MAP to kt/V. however, Kt/V showed significant negative correlation (r=-0.574,p<0.009) to MAP. Patients with Kt/V≥1.4 had significantly lowere platelet 〔Ca²+〕i (88 ± 19 vs 126 ± 17 nmol/L,p<0.01) and lower MAP (91 ± 9 vs 110 ± 12 mmHg,p<0.01) than did the patients with Kt/V<1.4. In conclusion, these results demonstrate the close interrelationship between platelet 〔Ca²+〕i, MAP and Kt/V in uremic patients on maintenance HD. Patients with higher doses of dialysis have lower platelet 〔Ca²+〕i and lower MAP before HD treatment. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。