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題 名 | Regulation of Vascular Endothelial Growth Factor Secretion in Human Meningioma Cells=人類腦膜瘤細胞分泌血管內皮生長因子之調節 |
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作 者 | 蔡瑞章; 蕭伊芸; 鄧麗珍; 孫家棟; 陳進庭; 高明見; | 書刊名 | 臺灣醫學會雜誌 |
卷 期 | 98:2 1999.02[民88.02] |
頁 次 | 頁111-117 |
分類號 | 415.149 |
關鍵詞 | 人類; 腦膜瘤細胞; 分泌; 血管內皮生長因子; Vascular endothelial growth factor; Vascular permeability factor; Meningioma; Growth factor; Sex hormone; Steroid; |
語 文 | 英文(English) |
英文摘要 | Previously, we induced vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) secretion in glioma cell lines by using physiologic concentrations of epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), or platelet-derived growth factor-BB (PDGF-BB). We hypothesized that VEGF/VPF might enhance the blood supply required for the unregulated growth of tumors, and that it acts as the central mediator of tumor angiogenesis. The objective of this study was to determine whether the expression of VEGF/VPF by meningiomas is regulated by growth factors or sex hormones. By means of an enzyme-linked immunosorbent assay of CH-157MN meningioma cell supernatants, we demonstrated that EGF and bFGF similarly induce VEGF secretion by CH-157MN meningioma cells. At the maximum concentrations of EGF (50ng/mL) and bFGF (50ng/mL) used in this study, VEGF secretion was induced to 140% to 160% above baseline constitutive secretion. PDGF-BB homodimer did not enhance VEGF secretion significantly. Estradiol (up to 10 �笐� mol/L ), progesterone (up to 10 �笐� mol/L ), or testosterone (up to 10 �笐� mol/L ) did not stimulate or inhibit VEGF secretion in CH-157MN meningioma cells (p>0.05). Furthermore, we demonstrated that dexamethasone decreased VEGF secretion to 32% of baseline constitutive secretion. This might explain the effect of corticosteroids in alleviating peritumoral brain edema in meningiomas. These results suggest that VEGF secretion in CH-157MN meningioma cells is mainly regulated by growth factors and corticosteroids, but not by sex hormones. Understanding the regulatin of VEGF/VPF secretion in meningiomas might contribute to the development of a new therapeutic strategy. |
本系統中英文摘要資訊取自各篇刊載內容。