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頁籤選單縮合
題名 | 卵巢過度刺激症候群的治療與預防=Review of Treatment and Prevention of Ovarian Hyperstimulation Syndrome |
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作 者 | 康智能; 余政穎; | 書刊名 | 藥學雜誌 |
卷期 | 26:3=104 2010.09[民99.09] |
頁次 | 頁124-130 |
分類號 | 417.3 |
關鍵詞 | 卵巢過度刺激症候群; 血管內皮生長因子; 人類絨毛膜促性腺激素; Ovarian hyperstimulation syndrome; Human chorionic gonadotropin; Vascular endothelial growth factor; |
語文 | 中文(Chinese) |
中文摘要 | 卵巢過度刺激症候群是使用受孕藥,如促性腺素、人類絨毛膜促性腺激素所引起的併發症。在臨床上,卵巢過度刺激症候群是依臨床症狀的嚴重性和檢驗數值分為三個等級;在病理學上,卵巢過度刺激症候群是一種複雜的反應。首先,助孕藥(如人類絨毛膜促性腺激素等)誘導多個濾泡發展變成多個卵巢囊腫,之後這些卵巢囊腫擴大和增加微血管的通透性,導致血管內液體流出血管外轉移到第三腔室(如腹腔),同時血管內液體減少導致腎臟灌流變少。在最嚴重的病例中,病人可能會腎臟衰竭、低容積休克和死亡。 一系列的研究發現,許多血管新生因子和血管活性激酶,如血管內皮生長因子(VEGF)、白細胞介素 -6,8(interleukin-6,8)、腫瘤壞死因子 -α(TNF-α)、血管收縮素 II都可能參與卵巢過度刺激症候群的成因和併發症。在這裡我們除回顧文獻探討卵巢過度刺激症候群病理生理學機轉,並進一步討論臨床上的治療和預防的方式。了解卵巢過度刺激症候群可能機轉、臨床預防及治療可協助藥師在不孕治療上多發揮角色。 |
英文摘要 | Ovarian hyperstimulation syndrome (OHSS) is a complication from certain fertility medication, like gonadotropin or human chorionic gonadotropin (hCG). Clinically, OHSS is classified into three grades by the severity of clinical symptoms and laboratory findings. In pathophysiology, OHSS results from a series of complex reactions. Firstly, fertility medications induce multifollicular development to become multiple ovarian cysts. Those ovarian cysts enlarge with increased capillary permeability. Thus results in not only fluid shift form intravascular space to the third space (like abdominal cavity) but also renal inflow decreasing. In the most severe cases, patients may be in renal failure, hypovolemic shock, and resulting in death. A series of studies have shown that several angiogenic and vasoactive cytokines, including vascular endothelial growth factor (VEGF), interleukin-6,8 (IL-6,8), tumor necrosis factor-α (TNF-α) and angiotension II are attributing pathogenetic factors for OHSS development and its complications. In this review, we describe the possible pathways about OHSS and its prevention and treatment to help pharmacist to deal with infertility therapy in clinical practice. |
本系統之摘要資訊系依該期刊論文摘要之資訊為主。