頁籤選單縮合
題 名 | Infection with Coagulase-Negative Staphylococci in a Neonatal Intensive Care Unit=新生兒重症照護中心凝結酶陰性葡萄球菌之感染 |
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作 者 | 邱麗雯; 黃永豐; 陳英堯; 謝凱生; 張學文; | 書刊名 | 醫學研究 |
卷 期 | 20:9 2000.12[民89.12] |
頁 次 | 頁481-487 |
分類號 | 419.38 |
關鍵詞 | 凝結酶陰性葡萄球菌; 抗生素敏感度; 危險因子; Coagulase negative staphylococci; Antimicrobial susceptibility; Risk factor; |
語 文 | 英文(English) |
中文摘要 | 凝結酶陰性葡萄球菌是在許多新生兒加護病房中院內感染最常見之致病原,為了進一步瞭解與此感染最相關之危險因子及此菌對抗生素的敏感度,本研究收集了高雄榮總新生兒加護病房從1994年至1998年血液培養凝結酶陰性葡萄球菌的病例,總共70例;我們將從多套血液培養出相同菌種並且合併有臨床症狀者視為感染組,感染組共23例;而另外則有47例為污染組,經由回歸統計找出最有相關的危險因子,我們發現以放置中央靜脈導管(p=0.0001)和CRP值的上升(p=0.001)是最具相關性。大部份的菌種(96%)皆具多種抗生素抗藥性,但卻對vancomycin皆具敏感性。感染組的病例在經過適當的抗生素治療及移除導管後並無死亡病例產生。 我們的結論是放置中央靜脈導管和CRP值的上升是與眞正感染最具相關性而非只是汙染Vancomycin仍是治療凝結酶陰性葡萄球菌唯一持續有效的抗生素。 |
英文摘要 | Coagulase-negative staphylococci (CNS) are currently the most common pathogens associated with hospital-acquired infection in many neonatal intensive care units. To determine the risk factors and antimicrobial susceptibility of infections with these organisms, we studied 70 infants from whose blood cultures grew CNS; these infants had received the neonatal intensive care at the Veterans General Hospital, Kaohsiung, Taiwan from 1994 to 1998. We considered it infected when the case grew the same isolates from multiple blood cultures and complied with clinical symptom and signs. Twenty-three cases of all were identified representing infection group and forty-seven were contamination group. Logistic regression was then performed to find significant correlates. The factors most significantly related with infection were the indwelling of central venous catheter (p=0.001) and increased C-reactive protein (CRP) (p=0.0001). Most strains (96%) were multiple antibiotic resistance but all were sensitive to vancomycin. After empirical antimicrobial therapy and by removing central venous catheter, we did not discover any directly associated mortality. We concluded that the indwelling of central venous catheter and increased titers of CRP correlate most strongly with true infection rather than contamination. Vancomycin is the only antibiotic with consistent efficacy against CNS. |
本系統中英文摘要資訊取自各篇刊載內容。