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題 名 | 核苷與核苷酸混合物對老化促進小白鼠學習記憶能力之影響=Effect of Nucleoside-Nucleotide Mixture on Learning and Memory in Senescence Accelerated Mice |
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作 者 | 詹吟菁; 吳青蓮; 梁雅芳; 王銘富; | 書刊名 | 中華民國營養學會雜誌 |
卷 期 | 25:1 2000.03[民89.03] |
頁 次 | 頁38-46 |
分類號 | 411.3 |
關鍵詞 | 核苷與核苷酸混合物; 學習記憶; SAMP8系小白鼠; 脂褐質; Nucleoside-nucleotide mixture; Learning and memory; Senescence accelerated mice; Lipofuscin; |
語 文 | 中文(Chinese) |
中文摘要 | 本研究目的在探討添加核?與核?酸混合物(nucleoside-nucleotide mixture; NNM)對學習記憶能力之影響。以20%酪蛋白(對照組)及20%酪蛋白添加0.5%NNM餵飼1及7月齡之雄性老化促進小白鼠(senescence accelerated mouse; SMAP8)。12週後,以單次被動迴避試驗(single-trial passive avoidance test)及主動迴避試驗(shuttle avoidance test)測試小白鼠之學習與記憶能力,實驗結束後犧牲動物,觀察腦部病理變化。結果顯示,同月齡兩組間之體重、攝食量及活動量均無顯著性差異。學習記憶方面,1月齡NNM組之學習記憶能力與對照組間無顯著性差異;7月齡NNM組小白鼠的學習記憶能力與對照組比較有顯著增加(p<0.05)。腦部組織病理方面,SAMP8系小白鼠之脂褐質主要集中在腦幹區;NNM組小白鼠比對照組有脂褐質減少的傾向。由以上實驗結果得知,添知0.5% NNM對7月齡記憶缺損小白鼠,可提高其學習記憶能力及減少腦部脂褐質之發生。 |
英文摘要 | The purposes of this study were to examine the effect of 0.5% nucleoside-nucleotide mixture (NNM) supplement on learning and memory. After 12 weeks of feeding, the learning and memory of 1 and 7 months old male senescence accelerated mice (SAMP8) were assessed using single-trial passive avoidance and shuttle avoidance tests. The mice were sacrificed to examine the brain pathology. The results showed that there were no significant differences in body weight gain, food intake or locomotion between the two groups. The NNM group had better learning and memory than the control in 1 month old mice, but not significantly different, whereas seven months old SAMP8 fed with NNM were significantly better than the control group (p < 0.05). The lipofuscin was mainly found in the brain stem. The NNM groups had lower lipofuscin than the control groups in both the 1 and 7 months old mice. In conclusion, the NNM supplement can improve learning and memory abilities, and decrease brain lipofuscin in 7 months old mice. |
本系統中英文摘要資訊取自各篇刊載內容。