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題 名 | 鋁誘發懷孕母鼠血漿中一氧化氮產物的增加與相關貧血指標變化之關係=Aluminum Induced Plasma Nitrite/Nitrate Elevation and Anemia-related Index Changes in Pregnant Rats |
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作 者 | 郭志宏; 郭宗甫; 王果行; | 書刊名 | 中華民國營養學會雜誌 |
卷 期 | 25:1 2000.03[民89.03] |
頁 次 | 頁9-16 |
分類號 | 415.513 |
關鍵詞 | 鋁; 一氧化氮; 貧血; 懷孕母鼠; Aluminum; Nitric oxide; Anemia; Pregnant rats; |
語 文 | 中文(Chinese) |
中文摘要 | 一氧化氮之大量形成,在發生貧血之可能機制上扮演重要的角色。因此本研究旨在評估口服氯化鋁是否誘發血漿中一氧化氮產物的大量形成,以及與相關貧血指標變化之關係。三組Winstar母鼠(每組15隻)於懷孕第8天至第11天分別給予口服0、74、185mg Al/kg/day之氯化鋁後,在懷孕第14天時發現隨著口服鋁劑量的遞增,其血漿中鋁濃度及一氧化氮產物明顯較對照組高。高鋁(185mg/kg)組的紅血球數、血紅素值、血球容積比及血漿中鋁濃度與一氧化氮產物之濃度呈明顯正相關性(r=0.874, p<0.05),而血漿中一氧化氮的濃度亦與紅血球數、血紅素值、血球容積比、或血漿鐵濃度呈明顯的負相關性(r=-0.634, -0.651, -0.634, -0.677, p<0.05)。以上結果顯示:口服鋁誘發懷孕母鼠血漿中一氧化氮濃度的增加,可能是鋁干擾造血作用引起貧血之主要機制之一。 |
英文摘要 | The formation of nitric oxide (NO) may play an important role in the underlying causes of the anemia. In this study, the effect of orally administrated aluminum chloride (AlCl3) on plasma NOx (total NO2-/No3-) levels, and the relationships between NOx production and anemia-related index were investigated. Pregnant female rats were randomly divided into three groups, each consisting of 15 animals. AlCl3 was gavaged at doses of 0, 74 or 185 mg Al/kg body wt/day respectively during pregnancy days 8 to 11. On pregnant day 14, the plasma NOx products were markedly increased following increased plasma level of Al (r = 0.874, p<0.05). In addition, the erythrocytes, hemoglobin, hematocrit, and plasma iron concentrations were significantly lower in Al-treated rats (185 mg Al/kg), compared with controls (p<0.05). The plasma NOx concentrations were inversely related to erythrocytes, hemoglobin, hematocrit and plasma iron values (r = -0.634, -0.651, -0.634, -0.677, p<0.05). These results indicated that Al-intoxication causes increased NOx production in the plasma, which may be associated with the hematopoiesis-system disturbance which may induce anemia. |
本系統中英文摘要資訊取自各篇刊載內容。